plos genetics سال:2010 - دوره:6

Fa | Ar | En


plos genetics
سال:2010 - دوره:6 - شماره:8

A developmental timing switch promotes axon outgrowth independent of known guidance receptors A deviation from the bipolar-tetrapolar mating paradigm in an early diverged basidiomycete A global overview of the genetic and functional diversity in the helicobacter pylori cag pathogenicity island A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice A model for damage load and its implications for the evolution of bacterial aging A wnt-frz/ror-dsh pathway regulates neurite outgrowth in caenorhabditis elegans An alpha-catulin homologue controls neuromuscular function through localization of the dystrophin complex and BK channels in Caenorhabditis elegans Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction Chromosome axis defects induce a checkpoint-mediated delay and interchromosomal effect on crossing over during drosophila meiosis Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits Conserved role of unc-79 in ethanol responses in lightweight mutant mice Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups Did genetic drift drive increases in genome complexity? Disease-associated mutations that alter the RNA structural ensemble Dynamic chromatin organization during foregut development mediated by the organ selector gene PHA-4/FoxA Dynamics of RAD9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity Epigenetically-inherited centromere and neocentromere DNA replicates earliest in s-phase Extracellular dopamine potentiates Mn-induced oxidative stress,lifespan reduction,and dopaminergic neurodegeneration in a BLI-3-dependent manner in caenorhabditis elegans Genetic analysis of baker's yeast msh4-msh5 reveals a threshold crossover level for meiotic viability Genome-wide association studies of serum magnesium,potassium,and sodium concentrations identify six loci influencing serum magnesium levels Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 shfm1 locus Identification of the bovine arachnomelia mutation by massively parallel sequencing implicates sulfite oxidase (SUOX) in bone development Inactivation of VCP/ter94 suppresses retinal pathology caused by misfolded Rhodopsin in Drosophila Methylated H3K4,a transcription-associated histone modification,is involved in the DNA damage response pathway Microtubule actin crosslinking factor 1 regulates the balbiani body and animal-vegetal polarity of the zebrafish oocyte Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis Multiple independent loci at chromosome 15q25.1 affect smoking quantity: A meta-analysis and comparison with lung cancer and COPD Multivesicular body formation requires OSBP-related proteins and cholesterol Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with charcot-marie-tooth disease RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition Something new: an interview with Radoje Drmanac. Interview by Jane Gitschier. Survival and growth of yeast without telomere capping by Cdc13 in the absence of Sgs1,Exo1,and Rad9 Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia The extinction dynamics of bacterial pseudogenes The transcriptomes of two heritable cell types illuminate the circuit governing their differentiation Transcriptional regulation by CHIP/LDB complexes Transmission of mitochondrial DNA diseases and ways to prevent them Tuberous sclerosis complex 1 regulates dE2f1 expression during development and cooperates with RBF1 to control proliferation and survival