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The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia
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نویسنده
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hsiung c.a. ,lan q. ,hong y.c. ,chen c.-j. ,dean hosgood h. ,chang i.-s. ,chatterjee n. ,brennan p. ,wu c. ,zheng w. ,chang g.-c. ,wu t. ,park j.y. ,hsiao c.-f. ,kim y.h. ,shen h. ,seow a. ,yeager m. ,tsai y.-h. ,kim y.t. ,chow w.-h. ,guo h. ,wang w.-c. ,sung s.w. ,hu z. ,chen k.-y. ,kim j.h. ,chen y. ,huang l. ,lee k.-m. ,lo y.-l. ,gao y.-t. ,kim j.h. ,liu l. ,huang m.-s. ,jung t.h. ,jin g. ,caporaso n. ,yu d. ,kim c.h. ,su w.-c. ,shu x.-o. ,xu p. ,kim i.-s. ,chen y.-m. ,ma h. ,shen m. ,cha s.i. ,tan w. ,chang c.-h. ,sung j.s. ,zhang m. ,yang t.-y. ,park k.h. ,yuenger j. ,wang c.-l. ,ryu j.-s. ,xiang y. ,deng q. ,hutchinson a. ,kim j.s. ,cai q. ,landi m.t. ,yu c.-j. ,park j.-y. ,tucker m. ,hung j.-y. ,lin c.-c. ,perng r.-p. ,boffetta p. ,chen c.-y. ,chen k.-c. ,yang s.-y. ,hu c.-y. ,chang c.-k. ,fraumeni jr. j.f. ,chanock s. ,yang p.-c. ,rothman n. ,lin d.
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منبع
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plos genetics - 2010 - دوره : 6 - شماره : 8
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چکیده
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Genome-wide association studies of lung cancer reported in populations of european background have identified three regions on chromosomes 5p15.33,6p21.33,and 15q25 that have achieved genome-wide significance with p-values of 10-7 or lower. these studies have been performed primarily in cigarette smokers,raising the possibility that the observed associations could be related to tobacco use,lung carcinogenesis,or both. since most women in asia do not smoke,we conducted a genome-wide association study of lung adenocarcinoma in never-smoking females (584 cases,585 controls) among han chinese in taiwan and found that the most significant association was for rs2736100 on chromosome 5p15.33 (p = 1.30×10-11). this finding was independently replicated in seven studies from east asia totaling 1,164 lung adenocarcinomas and 1,736 controls (p = 5.38×10-11). a pooled analysis achieved genome-wide significance for rs2736100. this snp marker localizes to the clptm1l-tert locus on chromosome 5p15.33 (p = 2.60×10-20,allelic risk = 1.54,95% confidence interval (ci) 1.41-1.68). risks for heterozygote and homozygote carriers of the minor allele were 1.62 (95% ci; 1.40-1.87),and 2.35 (95% ci: 1.95-2.83),respectively. in summary,our results show that genetic variation in the clptm1ltert locus of chromosome 5p15.33 is directly associated with the risk of lung cancer,most notably adenocarcinoma.
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آدرس
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division of biostatistics and bioinformatics,institute of population health sciences,national health research institutes,zhunan, Taiwan, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md, United States, department of preventive medicine,seoul national university college of medicine,seoul,south korea,institute of environmental medicine,seoul national university medical research center,seoul, South Korea, genomics research center,academia sinica,taipei,taiwan,graduate institute of epidemiology,college of public health,national taiwan university,taipei, Taiwan, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md, United States, national institute of cancer research,national health research institutes,zhunan, Taiwan, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md, United States, international agency for research on cancer,lyon, France, departments of etiology and carcinogenesis and state key laboratory of molecular oncology,cancer institute and hospital,chinese academy of medical science and peking union medical college,beijing, China, department of medicine,vanderbilt epidemiology center,institute for medicine and public health,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, division of chest medicine,department of internal medicine,taichung veterans general hospital,taichung,taiwan,institute of biomedical sciences,national chung-hsing university,taichung,taiwan,school of medicine,china medical university,taichung, Taiwan, institute of occupational medicine and ministry of education key lab for environment and health,school of public health,huazhong university of science and technology,wuhan, China, department of internal medicine,school of medicine,kyungpook national university,daegu,south korea,department of biochemistry,school of medicine,kyungpook national university,daegu,south korea,cancer research center,kyungpook national university hospital,daegu, South Korea, division of biostatistics and bioinformatics,institute of population health sciences,national health research institutes,zhunan, Taiwan, genomic research center for lung and breast/ovarian cancers,korea university anam hospital,seoul,south korea,department of internal medicine and division of brain,korea university college of medicine,seoul,south korea,division of oncology/hematology,department of internal medicine,korea university college of medicine,seoul, South Korea, department of epidemiology and biostatistics,cancer center,nanjing medical university,nanjing, China, department of epidemiology and public health,national university of singapore,singapore, Singapore, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md,united states,core genotyping facility,advanced technology program,national cancer institute,national institutes of health,department of health and human services,frederick,md, United States, department of pulmonary and critical care,chang gung memorial hospital,taiwan,department of respiratory care,chang gung university, Taiwan, cancer research institute,seoul national university college of medicine,seoul,south korea,department of thoracic and cardiovascular surgery,clinical research institute,seoul national university hospital,seoul, South Korea, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md, United States, institute of occupational medicine and ministry of education key lab for environment and health,school of public health,huazhong university of science and technology,wuhan, China, division of biostatistics and bioinformatics,institute of population health sciences,national health research institutes,zhunan, Taiwan, department of thoracic and cardiovascular surgery,seoul national university college of medicine,seoul,south korea,department of thoracic and cardiovascular surgery,seoul national university bundang hospital,geongi-do, South Korea, department of epidemiology and biostatistics,cancer center,nanjing medical university,nanjing, China, department of internal medicine,national taiwan university hospital,national taiwan university college of medicine,taipei, Taiwan, department of thoracic and cardiovascular surgery,clinical research institute,seoul national university hospital,seoul, South Korea, department of epidemiology and public health,national university of singapore,singapore, Singapore, departments of etiology and carcinogenesis and state key laboratory of molecular oncology,cancer institute and hospital,chinese academy of medical science and peking union medical college,beijing, China, department of preventive medicine,seoul national university college of medicine,seoul, South Korea, division of biostatistics and bioinformatics,institute of population health sciences,national health research institutes,zhunan, Taiwan, department of epidemiology,shanghai cancer institute,shanghai, China, department of preventive medicine,seoul national university college of medicine,seoul,south korea,institute of environmental medicine,seoul national university medical research center,seoul, South Korea, institute of occupational medicine and ministry of education key lab for environment and health,school of public health,huazhong university of science and technology,wuhan, China, department of internal medicine,kaohsiung medical university hospital,kaohsiung, Taiwan, department of internal medicine,school of medicine,kyungpook national university,daegu, South Korea, department of epidemiology and biostatistics,cancer center,nanjing medical university,nanjing, China, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md, United States, departments of etiology and carcinogenesis and state key laboratory of molecular oncology,cancer institute and hospital,chinese academy of medical science and peking union medical college,beijing, China, department of internal medicine,school of medicine,kyungpook national university,daegu, South Korea, department of internal medicine,national cheng kung university hospital,college of medicine,tainan, Taiwan, department of medicine,vanderbilt epidemiology center,institute for medicine and public health,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, institute of occupational medicine and ministry of education key lab for environment and health,school of public health,huazhong university of science and technology,wuhan, China, department of biochemistry,school of medicine,kyungpook national university,daegu, South Korea, chest department,taipei veterans general hospital,taipei,taiwan,school of medicine,national yang-ming university,taipei, Taiwan, department of epidemiology and biostatistics,cancer center,nanjing medical university,nanjing, China, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md, United States, department of internal medicine,school of medicine,kyungpook national university,daegu, South Korea, departments of etiology and carcinogenesis and state key laboratory of molecular oncology,cancer institute and hospital,chinese academy of medical science and peking union medical college,beijing, China, division of biostatistics and bioinformatics,institute of population health sciences,national health research institutes,zhunan, Taiwan, genomic research center for lung and breast/ovarian cancers,korea university anam hospital,seoul,south korea,department of internal medicine and division of brain,korea university college of medicine,seoul, South Korea, department of epidemiology and biostatistics,cancer center,nanjing medical university,nanjing, China, division of chest medicine,department of internal medicine,taichung veterans general hospital,taichung, Taiwan, genomic research center for lung and breast/ovarian cancers,korea university anam hospital,seoul,south korea,division of oncology/hematology,department of internal medicine,korea university college of medicine,seoul, South Korea, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md,united states,core genotyping facility,advanced technology program,national cancer institute,national institutes of health,department of health and human services,frederick,md, United States, department of pulmonary and critical care,chang gung memorial hospital, Taiwan, department of internal medicine,inha university college of medicine,incheon, South Korea, department of epidemiology,shanghai cancer institute,shanghai, China, institute of occupational medicine and ministry of education key lab for environment and health,school of public health,huazhong university of science and technology,wuhan, China, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md,united states,core genotyping facility,advanced technology program,national cancer institute,national institutes of health,department of health and human services,frederick,md, United States, genomic research center for lung and breast/ovarian cancers,korea university anam hospital,seoul,south korea,department of internal medicine and division of brain,korea university college of medicine,seoul,south korea,division of oncology/hematology,department of internal medicine,korea university college of medicine,seoul, South Korea, department of medicine,vanderbilt epidemiology center,institute for medicine and public health,vanderbilt-ingram cancer center,vanderbilt university school of medicine,nashville,tn, United States, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md, United States, department of internal medicine,national taiwan university hospital,national taiwan university college of medicine,taipei, Taiwan, cancer research institute,seoul national university college of medicine,seoul, South Korea, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md, United States, department of internal medicine,kaohsiung medical university hospital,kaohsiung, Taiwan, department of internal medicine,national cheng kung university hospital,college of medicine,tainan, Taiwan, chest department,taipei veterans general hospital,taipei, Taiwan, international agency for research on cancer,lyon, France, cancer center,china medical university hospital,taipei, Taiwan, division of chest medicine,department of internal medicine,taichung veterans general hospital,taichung, Taiwan, graduate institute of epidemiology,college of public health,national taiwan university,taipei, Taiwan, division of biostatistics and bioinformatics,institute of population health sciences,national health research institutes,zhunan, Taiwan, division of biostatistics and bioinformatics,institute of population health sciences,national health research institutes,zhunan, Taiwan, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md, United States, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md,united states,core genotyping facility,advanced technology program,national cancer institute,national institutes of health,department of health and human services,frederick,md,united states,laboratory of translational genomics,division of cancer epidemiology and genetics,national cancer institute,national institutes of health,department of health and human services,bethesda,md, United States, department of internal medicine,national taiwan university hospital,national taiwan university college of medicine,taipei, Taiwan, division of cancer epidemiology,national cancer institute,national institutes of health,department of health and human services,bethesda,md, United States, departments of etiology and carcinogenesis and state key laboratory of molecular oncology,cancer institute and hospital,chinese academy of medical science and peking union medical college,beijing, China
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Authors
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