plos genetics سال:2011 - دوره:7

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plos genetics
سال:2011 - دوره:7 - شماره:12

A High-Resolution Whole-Genome map of key chromatin modifications in the adult Drosophila melanogaster A complex genomic rearrangement involving the Endothelin 3 locus causes dermal hyperpigmentation in the chicken A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap A densely interconnected genome-wide network of micrornas and oncogenic pathways revealed using gene expression signatures A functional phylogenomic view of the seed plants A genetic screening strategy identifies novel regulators of the proteostasis network A novel checkpoint and RPA inhibitory pathway regulated by Rif1 A population genetics-phylogenetics approach to inferring natural selection in coding sequences Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1 Age-related neuronal degeneration: Complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology An Anti-Checkpoint activity for Rif1 An assessment of the individual and collective effects of variants on height using twins and a developmentally informative study design Ancestral components of admixed genomes in a Mexican cohort Autosomal recessive dilated cardiomyopathy due to DOLK mutations results from abnormal dystroglycan O-mannosylation Azospirillum genomes reveal transition of bacteria from aquatic to terrestrial environments Candidate gene screen in the red flour beetle tribolium reveals six3 as ancient regulator of anterior median head and central complex development Charcot-marie-tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels Common variants show predicted polygenic effects on height in the tails of the distribution,except in extremely short individuals DNA methylation of the gonadal aromatase (cyp19a) promoter is involved in temperature-dependent sex ratio shifts in the European sea bass Drosophila ribosomal protein mutants control tissue growth non-autonomously via effects on the prothoracic gland and ecdysone Duox,Flotillin-2,and Src42A are required to activate or delimit the spread of the transcriptional response to epidermal wounds in Drosophila Genome instability and transcription elongation impairment in human cells depleted of THO/TREX Genome-wide meta-analysis of five asian cohorts identifies pdgfra as a susceptibility locus for corneal astigmatism Genomic distribution and Inter-Sample variation of Non-CpG methylation across human cell types HIF-1 regulates iron homeostasis in caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage Hierarchical generalized linear models for multiple groups of rare and common variants: Jointly estimating group and Individual-Variant effects Histone H3K9 trimethylase eggless controls germline stem cell maintenance and differentiation Identification of a genomic reservoir for new trim genes in primate genomes Identification of evolutionarily conserved exons as regulated targets for the splicing activator Tra2β in development Integrating Genome-Wide genetic variations and monocyte expression data reveals Trans-Regulated gene modules in humans Interspecific sex in grass smuts and the genetic diversity of their pheromone-receptor system MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila Mechanisms establishing tlr4-responsive activation states of inflammatory response genes Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol Plasticity of BRCA2 function in homologous recombination: Genetic interactions of the PALB2 and DNA binding domains Repetitive elements may comprise over Two-Thirds of the human genome Ror2 enhances polarity and directional migration of primordial germ cells SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus Substitutions in the Amino-Terminal tail of Neurospora histone H3 have varied effects on DNA methylation Target site recognition by a diversity-generating retroelement Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-ogna The FGFR4-G388R polymorphism promotes mitochondrial STAT3 serine phosphorylation to facilitate pituitary growth hormone cell tumorigenesis The RNA silencing enzyme RNA polymerase V is required for plant immunity The RNA-methyltransferase misu (NSun2) poises epidermal stem cells to differentiate The caenorhabditis elegans synthetic multivulva genes prevent ras pathway activation by tightly repressing global ectopic expression of lin-3 EGF The connection between space and thinking: An interview with Rafael Viñoly The fission yeast Stress-Responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved Transcription is required to establish maternal imprinting at the Prader-Willi syndrome and Angelman syndrome locus Widespread cotranslational formation of protein complexes