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Genome-wide meta-analysis of five asian cohorts identifies pdgfra as a susceptibility locus for corneal astigmatism
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نویسنده
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fan q. ,zhou x. ,khor c.-c. ,cheng c.-y. ,goh l.-k. ,sim x. ,tay w.-t. ,li y.-j. ,ongrick t.-h. ,suo c. ,cornes b. ,ikram m.k. ,chia k.-s. ,seielstad m. ,liu j. ,vithana e. ,young t.l. ,tai e.-s. ,wong t.-y. ,aung t. ,teo y.-y. ,saw s.-m.
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منبع
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plos genetics - 2011 - دوره : 7 - شماره : 12
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چکیده
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Corneal astigmatism refers to refractive abnormalities and irregularities in the curvature of the cornea,and this interferes with light being accurately focused at a single point in the eye. this ametropic condition is highly prevalent,influences visual acuity,and is a highly heritable trait. there is currently a paucity of research in the genetic etiology of corneal astigmatism. here we report the results from five genome-wide association studies of corneal astigmatism across three asian populations,with an initial discovery set of 4,254 chinese and malay individuals consisting of 2,249 cases and 2,005 controls. replication was obtained from three surveys comprising of 2,139 indians,an additional 929 chinese children,and an independent 397 chinese family trios. variants in pdgfra on chromosome 4q12 (lead snp: rs7677751,allelic odds ratio = 1.26 (95% ci: 1.16-1.36),p meta = 7.87×10 -9) were identified to be significantly associated with corneal astigmatism,exhibiting consistent effect sizes across all five cohorts. this highlights the potential role of variants in pdgfra in the genetic etiology of corneal astigmatism across diverse asian populations. © 2011 fan et al.
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آدرس
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school of public health,national university of singapore,singapore, Singapore, school of public health,national university of singapore,singapore, Singapore, genome institute of singapore,agency for science,technology,and research,singapore,singapore,singapore eye research institute,singapore national eye centre,singapore,singapore,centre for molecular epidemiology,national university of singapore,singapore,singapore,department of pediatrics,national university of singapore,singapore, Singapore, school of public health,national university of singapore,singapore,singapore,singapore eye research institute,singapore national eye centre,singapore,singapore,department of ophthalmology,national university of singapore,singapore, Singapore, school of public health,national university of singapore,singapore,singapore,duke-national university of singapore graduate medical school,singapore,singapore,department of medical oncology,national cancer centre singapore,singapore, Singapore, centre for molecular epidemiology,national university of singapore,singapore, Singapore, singapore eye research institute,singapore national eye centre,singapore, Singapore, center for human genetics,duke university medical center,durham,nc,united states,department of biostatistics and bioinformatics,duke university medical center,durham,nc, United States, school of public health,national university of singapore,singapore,singapore,nus graduate school for integrative science and engineering,national university of singapore,singapore, Singapore, centre for molecular epidemiology,national university of singapore,singapore, Singapore, singapore eye research institute,singapore national eye centre,singapore, Singapore, school of public health,national university of singapore,singapore,singapore,singapore eye research institute,singapore national eye centre,singapore,singapore,duke-national university of singapore graduate medical school,singapore,singapore,department of ophthalmology,erasmus medical center,rotterdam, Netherlands, school of public health,national university of singapore,singapore,singapore,centre for molecular epidemiology,national university of singapore,singapore,singapore,nus graduate school for integrative science and engineering,national university of singapore,singapore, Singapore, institute for human genetics and department of laboratory medicine,university of california san francisco,san francisco,ca, United States, genome institute of singapore,agency for science,technology,and research,singapore, Singapore, singapore eye research institute,singapore national eye centre,singapore,singapore,department of ophthalmology,national university of singapore,singapore, Singapore, center for human genetics,duke university medical center,durham,nc, United States, school of public health,national university of singapore,singapore,singapore,department of medicine,national university of singapore,singapore, Singapore, school of public health,national university of singapore,singapore,singapore,singapore eye research institute,singapore national eye centre,singapore,singapore,department of ophthalmology,national university of singapore,singapore,singapore,centre for eye research australia,university of melbourne,melbourne, Australia, singapore eye research institute,singapore national eye centre,singapore,singapore,department of ophthalmology,national university of singapore,singapore, Singapore, school of public health,national university of singapore,singapore,singapore,genome institute of singapore,agency for science,technology,and research,singapore,singapore,singapore eye research institute,singapore national eye centre,singapore,singapore,nus graduate school for integrative science and engineering,national university of singapore,singapore,singapore,department of statistics and applied probability,national university of singapore,singapore, Singapore, school of public health,national university of singapore,singapore,singapore,singapore eye research institute,singapore national eye centre,singapore,singapore,department of ophthalmology,national university of singapore,singapore,singapore,nus graduate school for integrative science and engineering,national university of singapore,singapore, Singapore
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Authors
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