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prefrontal cortical thinning links to negative symptoms in schizophrenia via the enigma consortium
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نویسنده
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walton e. ,hibar d.p. ,van erp t.g.m. ,potkin s.g. ,roiz-santiañez r. ,crespo-facorro b. ,suarez-pinilla p. ,van haren n.e.m. ,de zwarte s.m.c. ,kahn r.s. ,cahn w. ,doan n.t. ,jorgensen k.n. ,gurholt t.p. ,agartz i. ,andreassen o.a. ,westlye l.t. ,melle i. ,berg a.o. ,morch-johnsen l. ,færden a. ,flyckt l. ,fatouros-bergman h. ,jönsson e.g. ,hashimoto r. ,yamamori h. ,fukunaga m. ,jahanshad n. ,de rossi p. ,piras f. ,banaj n. ,spalletta g. ,gur r.e. ,gur r.c. ,wolf d.h. ,satterthwaite t.d. ,beard l.m. ,sommer i.e. ,koops s. ,gruber o. ,richter a. ,krämer b. ,kelly s. ,donohoe g. ,mcdonald c. ,cannon d.m. ,corvin a. ,gill m. ,di giorgio a. ,bertolino a. ,lawrie s. ,nickson t. ,whalley h.c. ,neilson e. ,calhoun v.d. ,thompson p.m. ,turner j.a. ,ehrlich s.
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منبع
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psychological medicine - 2018 - دوره : 48 - شماره : 1 - صفحه:82 -94
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چکیده
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Background our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates of schizophrenia. research showed that impairments in value processing and executive functioning, which have been associated with prefrontal brain areas [particularly the medial orbitofrontal cortex (mofc)], are linked to negative symptoms. here we tested the hypothesis that mofc thickness is associated with negative symptom severity. methods this study included 1985 individuals with schizophrenia from 17 research groups around the world contributing to the enigma schizophrenia working group. cortical thickness values were obtained from t1-weighted structural brain scans using freesurfer. a meta-analysis across sites was conducted over effect sizes from a model predicting cortical thickness by negative symptom score (harmonized scale for the assessment of negative symptoms or positive and negative syndrome scale scores). results meta-analytical results showed that left, but not right, mofc thickness was significantly associated with negative symptom severity (β std = -0.075; p = 0.019) after accounting for age, gender, and site. this effect remained significant (p = 0.036) in a model including overall illness severity. covarying for duration of illness, age of onset, antipsychotic medication or handedness weakened the association of negative symptoms with left mofc thickness. as part of a secondary analysis including 10 other prefrontal regions further associations in the left lateral orbitofrontal gyrus and pars opercularis emerged. conclusions using an unusually large cohort and a meta-analytical approach, our findings point towards a link between prefrontal thinning and negative symptom severity in schizophrenia. this finding provides further insight into the relationship between structural brain abnormalities and negative symptoms in schizophrenia.
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کلیدواژه
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cortical thickness ,enigma ,freesurfer ,medial orbitofrontal cortex ,mri ,negative symptoms ,panss ,sans ,schizophrenia
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آدرس
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king's college london, institute of psychology psychiatry and neuroscience, department of psychology, uk. georgia state university, department of psychology, usa. technische universität dresden, faculty of medicine, division of psychological and social medicine and developmental neurosciences, germany, university of southern california, mark and mary stevens institute for neuroimaging and informatics, imaging genetics center, usa, university of california, department of psychiatry and human behavior, uk, university of california, department of psychiatry and human behavior, uk, university of cantabria-idival, school of medicine, university hospital marqués de valdecilla, department of psychiatry, spain. cibersam (centro investigación biomédica en red salud mental), spain, university of cantabria-idival, school of medicine, university hospital marqués de valdecilla, department of psychiatry, spain. cibersam (centro investigación biomédica en red salud mental), spain, university of cantabria-idival, school of medicine, university hospital marqués de valdecilla, department of psychiatry, spain. cibersam (centro investigación biomédica en red salud mental), spain, university medical center utrecht, brain center rudolf magnus, department of psychiatry, netherlands, university medical center utrecht, brain center rudolf magnus, department of psychiatry, netherlands, university medical center utrecht, brain center rudolf magnus, department of psychiatry, netherlands, university medical center utrecht, brain center rudolf magnus, department of psychiatry, netherlands, university of oslo, kg jebsen centre for psychosis research, division of mental health and addiction, norway, university of oslo, kg jebsen centre for psychosis research, norment, division of mental health and addiction, norway. diakonhjemmet hospital, department of psychiatric research, norway, university of oslo, kg jebsen centre for psychosis research, norment, division of mental health and addiction, norway, karolinska institutet, department of clinical neuroscience, sweden. university of oslo, kg jebsen centre for psychosis research, norment, division of mental health and addiction, norway. diakonhjemmet hospital, department of psychiatric research, norway, karolinska institutet, department of clinical neuroscience, sweden. university of oslo, kg jebsen centre for psychosis research, norment, division of mental health and addiction, norway, university of oslo, kg jebsen centre for psychosis research, norment, division of mental health and addiction, norway, university of oslo, kg jebsen centre for psychosis research, division of mental health and addiction, norway, university of oslo, kg jebsen centre for psychosis research, norment, division of mental health and addiction, norway, diakonhjemmet hospital, department of psychiatric research, norway. university of oslo, kg jebsen centre for psychosis research, norment, division of mental health and addiction, norway, oslo university hospital, division of mental health and addiction, norway, centre for psychiatry research, karolinska institutet, department of clinical neuroscience, sweden, centre for psychiatry research, karolinska institutet, department of clinical neuroscience, sweden, karolinska institutet, department of clinical neuroscience, sweden. university of oslo, kg jebsen centre for psychosis research, norment, division of mental health and addiction, norway, osaka university, united graduate school of child development, molecular research center for children's mental development, graduate school of medicine, department of psychiatry, japan, osaka university, graduate school of medicine, department of psychiatry, japan, national institute for physiological sciences, division of cerebral integration, japan, university of southern california, mark and mary stevens institute for neuroimaging and informatics, imaging genetics center, usa, sapienza university, school of medicine and psychology, department of neurology and psychiatry, nesmos department (neurosciences mental health and sensory functions), italy. irccs santa lucia foundation, department of clinical and behavioural neurology, italy, irccs santa lucia foundation, department of clinical and behavioural neurology, italy. centro fermi - museo storico della fisica e centro studi e ricerche enrico fermi, italy, irccs santa lucia foundation, department of clinical and behavioural neurology, italy, baylor college of medicine houstontx, department of psychiatry and behavioral sciences, beth k. and stuart c. yudofsky division of neuropsychiatry menninger, usa. irccs santa lucia foundation, department of clinical and behavioural neurology, italy, university of pennsylvania, brain behavior laboratory, usa, university of pennsylvania, brain behavior laboratory, usa, university of pennsylvania, brain behavior laboratory, usa, university of pennsylvania, brain behavior laboratory, usa, university of pennsylvania, brain behavior laboratory, usa, university medical center utrecht, brain center rudolf magnus, department of psychiatry, netherlands, university medical center utrecht, brain center rudolf magnus, department of psychiatry, netherlands, university medical center göttingen, center for translational research in systems neuroscience and psychiatry, department of psychiatry and psychotherapy, germany, university medical center göttingen, center for translational research in systems neuroscience and psychiatry, department of psychiatry and psychotherapy, germany, university medical center göttingen, center for translational research in systems neuroscience and psychiatry, department of psychiatry and psychotherapy, germany, trinity college, ireland. university of southern california, mark and mary stevens institute for neuroimaging and informatics, imaging genetics center, usa, national university of ireland galway, centre for neuroimaging and cognitive genomics (nicog), ncbes galway neuroscience centre, ireland, national university of ireland galway, centre for neuroimaging and cognitive genomics (nicog), ncbes galway neuroscience centre, ireland, national university of ireland galway, centre for neuroimaging and cognitive genomics (nicog), ncbes galway neuroscience centre, ireland, national university of ireland galway, centre for neuroimaging and cognitive genomics (nicog), ncbes galway neuroscience centre, ireland, trinity college, ireland, irccs casa sollievo della sofferenza, section of psychiatry and psychology, italy, university of bari 'aldo moro', psychiatric neuroscience group, italy, university of edinburgh, royal edinburgh hospital, division of psychiatry, uk, university of edinburgh, royal edinburgh hospital, division of psychiatry, uk, university of edinburgh, royal edinburgh hospital, division of psychiatry, uk, university of edinburgh, royal edinburgh hospital, division of psychiatry, uk, university of new mexico, department of electrical and computer engineering, usa. mind research network, usa, university of southern california, mark and mary stevens institute for neuroimaging and informatics, imaging genetics center, usa, georgia state university, neuroscience institute, department of psychology, usa, technische universität dresden, faculty of medicine, division of psychological and social medicine and developmental neurosciences, germany
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