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Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome
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نویسنده
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shigemura t. ,yamazaki t. ,hara y. ,ou j.-n. ,stevens a.m. ,ochs h.d. ,koike k. ,agematsu k.
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منبع
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pediatric rheumatology - 2011 - دوره : 9 - شماره : 0
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چکیده
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Systemic juvenile idiopathic arthritis (sjia) is a systemic inflammatory disease characterized by arthritis,spiking fever and a skin rash that is frequently complicated by macrophage activation syndrome (mas),a life-threatening disorder. we report a 22-month-old girl with sjia who developed severe mas but was successfully treated with corticosteroids,cyclosporin a,and non-steroidal anti-inflammatory drugs by monitoring serum il-18 levels. il-18 is an extremely useful cytokine for monitoring the activity of sjia and mas,and serum il-18 can be used as an indicator for the effectiveness of treatment and the decision to discontinue therapy.© 2011 shigemura et al; licensee biomed central ltd.
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آدرس
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department of pediatrics,shinshu university school of medicine,matsumoto 390-8621, Japan, department of pediatrics,shinshu university school of medicine,matsumoto 390-8621, Japan, department of pediatrics,shinshu university school of medicine,matsumoto 390-8621, Japan, seattle children's research institute,1900 9th avenue,seattle,wa 98101, United States, seattle children's research institute,1900 9th avenue,seattle,wa 98101, United States, seattle children's research institute,1900 9th avenue,seattle,wa 98101, United States, department of pediatrics,shinshu university school of medicine,matsumoto 390-8621, Japan, department of infection and host defense,shinshu university,graduate school of medicine,matsumoto 390-8621, Japan
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Authors
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