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Profiling anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis
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نویسنده
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tebo a.e. ,jaskowski t. ,davis k.w. ,whiting a. ,clifford b. ,zeft a. ,mcnally b. ,hill h.r. ,bohnsack j. ,prahalad s.
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منبع
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pediatric rheumatology - 2012 - دوره : 10 - شماره : 0
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چکیده
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Background: anti-citrullinated protein/peptide antibodies (acpa),have high specificity for rheumatoid arthritis (ra). some children with juvenile idiopathic arthritis (jia),phenotypically resemble ra and test positive for rheumatoid factor (rf) a characteristic biomarker of ra. we investigated the prevalence of acpa and its relationship to other serologic markers associated with ra in a well-characterized jia cohort.methods: cases were 334 children with jia,30 of whom had rf + polyarticular jia. sera from all cases and 50 healthy pediatric controls were investigated by elisa at a single time point for anti-cyclic citrullinated peptide (anti-ccp) igg,rf igm,iga and igg,anti-ra33 igg,and antinuclear antibodies (ana). comparisons between cases and controls were made using chi-square or fisher exact tests and t-tests.results: the prevalence of rf was 8% among controls,and 12% among cases (ns). the prevalence of acpa was 2% in controls and 14.3% in cases (or 8.2,p <0.01). children who were acpa-positive and rf-negative (n = 23) had a significantly earlier onset-age (4.6 years vs. 12.1 years,p <0.00001) and had fewer hla-drb1 shared epitope alleles than those positive for both rf and acpa (n = 25). prevalence of anti-ra33 was not different between cases and controls.conclusions: acpas are detectable in 14% of children with jia. children with positive acpa but negative rf are frequent,and may define a distinct subset of children with jia. acpa testing should be included in the classification of jia. © 2012 tebo et al.; licensee biomed central ltd.
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کلیدواژه
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Cyclic citrullinated peptide; Juvenile idiopathic arthritis; Rheumatoid arthritis; Serologic markers
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آدرس
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associated regional and university pathologists,institute for clinical and experimental pathology,salt lake city,ut,united states,department of pathology,university of utah,salt lake city,ut, United States, associated regional and university pathologists,institute for clinical and experimental pathology,salt lake city,ut, United States, associated regional and university pathologists,institute for clinical and experimental pathology,salt lake city,ut, United States, department of pediatrics,university of utah,salt lake city,ut, United States, department of pediatrics,university of utah,salt lake city,ut, United States, department of pediatrics,university of utah,salt lake city,ut, United States, department of pediatrics,university of utah,salt lake city,ut, United States, associated regional and university pathologists,institute for clinical and experimental pathology,salt lake city,ut,united states,department of pathology,university of utah,salt lake city,ut,united states,department of pediatrics,university of utah,salt lake city,ut,united states,department of medicine,university of utah,salt lake city,ut, United States, department of pediatrics,university of utah,salt lake city,ut, United States, department of pediatrics and human genetics,emory university school of medicine,2015 uppergate drive ne,atlanta,ga,30322,united states,children's healthcare of atlanta,atlanta,ga, United States
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Authors
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