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Gut microbiota-host interactions and juvenile idiopathic arthritis
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نویسنده
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arvonen m. ,berntson l. ,pokka t. ,karttunen t.j. ,vähäsalo p. ,stoll m.l.
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منبع
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pediatric rheumatology - 2016 - دوره : 14 - شماره : 1
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چکیده
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Background: juvenile idiopathic arthritis is the most common form of chronic arthritis in children. there is mounting evidence that the microbiota may influence the disease. main body: recent observations in several systemic inflammatory diseases including jia have indicated that abnormalities in the contents of the microbiota may be factors in disease pathogenesis,while other studies in turn have shown that environmental factors impacting the composition of the microbiota,such as delivery mode and early exposure to antibiotics,affect the risk of chronic inflammatory diseases including jia. microbial alterations may predispose to jia through a variety of mechanisms,including impaired immunologic development,alterations in the balances of pro- versus anti-inflammatory bacteria,and low-grade mucosal inflammation. additional confirmatory studies of microbiota aberrations and their risk factors are needed,as well as additional mechanistic studies linking these alterations to the disease itself. conclusions: the microbiota may influence the risk of jia and other systemic inflammatory conditions through a variety of mechanisms. additional research is required to improve our understanding of the links between the microbiota and arthritis,and the treatment implications thereof. © 2016 the author(s).
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کلیدواژه
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Antibiotics; Juvenile arthritis; Microbiota
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آدرس
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kuopio university hospital,department of pediatrics,kuopio,finland,oulu university hospital and university of oulu,medical research center,oulu,finland,university of oulu,pedego research unit,oulu, Finland, uppsala university,department of women's and children's health,uppsala, Sweden, oulu university hospital and university of oulu,medical research center,oulu,finland,university of oulu,pedego research unit,oulu,finland,oulu university hospital,department of children and adolescents,oulu, Finland, oulu university hospital and university of oulu,medical research center,oulu,finland,university of oulu,cancer and translational medicine research unit,oulu,finland,oulu university hospital,department of pathology,oulu, Finland, oulu university hospital and university of oulu,medical research center,oulu,finland,university of oulu,pedego research unit,oulu,finland,oulu university hospital,department of children and adolescents,oulu, Finland, university of alabama at birmingham,department of pediatrics,cpp n 210 m,1600 7th avenue south,birmingham,al 35233, United States
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Authors
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