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Methods for analyzing observational longitudinal prognosis studies for rheumatic diseases: A review & worked example using a clinic-based cohort of juvenile dermatomyositis patients
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نویسنده
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lim l.s.h. ,pullenayegum e. ,moineddin r. ,gladman d.d. ,silverman e.d. ,feldman b.m.
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منبع
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pediatric rheumatology - 2017 - دوره : 15 - شماره : 1
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چکیده
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Most outcome studies of rheumatic diseases report outcomes ascertained on a single occasion. while single assessments are sufficient for terminal or irreversible outcomes,they may not be sufficiently informative if outcomes change or fluctuate over time. consequently,longitudinal studies that measure non-terminal outcomes repeatedly afford a better understanding of disease evolution. longitudinal studies require special analytic methods. newer longitudinal analytic methods have evolved tremendously to deal with common challenges in longitudinal observational studies. in recent years,an increasing number of studies have used longitudinal design. this review aims to help readers understand and apply the findings from longitudinal studies. using a cohort of children with juvenile dermatomyositis (jdm),we illustrate how to study evolution of disease activity in jdm using longitudinal methods. © 2017 the author(s).
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کلیدواژه
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Biostatistics; Childhood-onset dermatomyositis; Epidemiology; Longitudinal study
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آدرس
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university of manitoba,children's hospital research institute of manitoba,winnipeg,canada,university of manitoba,department of pediatrics,winnipeg,canada,university of toronto,institute of health policy management and evaluation,toronto, Canada, the child health evaluative sciences program,sickkids research institute,toronto, Canada, university of toronto,department of family and community medicine,toronto, Canada, university of toronto,department of medicine,toronto western research institute,toronto,canada,toronto western hospital,centre for prognosis studies,university health network,toronto, Canada, division of rheumatology,sickkids,toronto,canada,physiology and experimental medicine program,sickkids research institute,toronto,canada,university of toronto,department of pediatrics and immunology,toronto, Canada, university of toronto,institute of health policy management and evaluation,toronto,canada,the child health evaluative sciences program,sickkids research institute,toronto,canada,division of rheumatology,sickkids,toronto,canada,university of toronto,department of pediatrics and immunology,toronto,canada,university of toronto,the dalla lana school of public health,toronto, Canada
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Authors
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