|
|
|
|
Growth and weight gain in children with juvenile idiopathic arthritis: Results from the ReACCh-Out cohort
|
|
|
|
|
|
|
|
نویسنده
|
guzman j. ,kerr t. ,ward l.m. ,ma j. ,oen k. ,rosenberg a.m. ,feldman b.m. ,boire g. ,houghton k. ,dancey p. ,scuccimarri r. ,bruns a. ,huber a.m. ,watanabe duffy k. ,shiff n.j. ,berard r.a. ,levy d.m. ,stringer e. ,morishita k. ,johnson n. ,cabral d.a. ,larché m. ,petty r.e. ,laxer r.m. ,silverman e. ,miettunen p. ,chetaille a.-l. ,haddad e. ,spiegel l. ,turvey s.e. ,schmeling h. ,lang b. ,ellsworth j. ,ramsey s.e. ,roth j. ,campillo s. ,benseler s. ,chédeville g. ,schneider r. ,tse s.m.l. ,bolaria r. ,gross k. ,feldman d. ,cameron b. ,jurencak r. ,dorval j. ,leblanc c. ,st. cyr c. ,gibbon m. ,yeung r.s.m. ,duffy c.m. ,tucker l.b.
|
|
منبع
|
pediatric rheumatology - 2017 - دوره : 15 - شماره : 1
|
|
چکیده
|
Background: with modern treatments,the effect of juvenile idiopathic arthritis (jia) on growth may be less than previously reported. our objective was to describe height,weight and body mass index (bmi) development in a contemporary jia inception cohort. methods: canadian children newly-diagnosed with jia 2005-2010 had weight and height measurements every 6months for 2years,then yearly up to 5years. these measurements were used to calculate mean age- and sex-standardized z-scores,and estimate prevalence and cumulative incidence of growth impairments,and the impact of disease activity and corticosteroids on growth. results: one thousand one hundred forty seven children were followed for median 35.5months. mean z-scores,and the point prevalence of short stature (height<2.5th percentile,2.5% to 3.4%) and obesity (bmi>95th percentile,15.8% to 16.4%) remained unchanged in the whole cohort. thirty-three children (2.9%) developed new-onset short stature,while 27 (2.4%) developed tall stature (>97.5th percentile). children with systemic arthritis (n=77) had an estimated 3-year cumulative incidence of 9.3% (95%ci: 4.3-19.7) for new-onset short stature and 34.4% (23-49.4) for obesity. most children (81.7%) received no systemic corticosteroids,but 1mg/kg/day prednisone-equivalent maintained for 6months corresponded to a drop of 0.64 height z-scores (0.56-0.82) and an increase of 0.74 bmi z-scores (0.56-0.92). an increase of 1 in the 10-cm physician global assessment of disease activity maintained for 6months corresponded to a drop of 0.01 height z-scores (0-0.02). conclusions: most children in this modern jia cohort grew and gained weight as children in the general population. about 1 in 10 children who had systemic arthritis,uncontrolled disease and/or prolonged corticosteroid use,had increased risk of growth impairment. © 2017 the author(s).
|
|
کلیدواژه
|
Corticosteroids; Growth; Juvenile arthritis; Obesity
|
|
آدرس
|
from british columbia children's hospital and university of british columbia,vancouver,canada,division of pediatric rheumatology,bc children's hospital,4500 oak st,suite k4-122,vancouver,bc v6h 3n1, Canada, division of pediatric rheumatology,bc children's hospital,4500 oak st,suite k4-122,vancouver,bc v6h 3n1, Canada, children's hospital of eastern ontario and university of ottawa,ottawa, Canada, children's hospital of eastern ontario and university of ottawa,ottawa, Canada, university of manitoba,department of pediatrics and child health,winnipeg, Canada, royal university hospital and university of saskatchewan,saskatoon, Canada, hospital for sick children and university of toronto,toronto, Canada, centre hospitalier universitaire de sherbrooke and université de sherbrooke,sherbrooke, Canada, from british columbia children's hospital and university of british columbia,vancouver, Canada, janeway children's health and rehabilitation centre and memorial university,saint john's, Canada, mcgill university health centre and mcgill university,montreal, Canada, centre hospitalier universitaire de sherbrooke and université de sherbrooke,sherbrooke, Canada, iwk health centre and dalhousie university,halifax, Canada, children's hospital of eastern ontario and university of ottawa,ottawa, Canada, shands children's hospital and university of florida,gainesville, United States, london health sciences centre and western university,london, Canada, hospital for sick children and university of toronto,toronto, Canada, iwk health centre and dalhousie university,halifax, Canada, from british columbia children's hospital and university of british columbia,vancouver, Canada, alberta children's hospital and university of calgary,calgary, Canada, from british columbia children's hospital and university of british columbia,vancouver, Canada, mcmaster university,hamilton, Canada, from british columbia children's hospital and university of british columbia,vancouver, Canada, hospital for sick children and university of toronto,toronto, Canada, hospital for sick children and university of toronto,toronto, Canada, alberta children's hospital and university of calgary,calgary, Canada, centre hospitalier universitaire de laval and université laval,quebec, Canada, centre hospitalier universitaire ste. justine and université de montréal,montréal, Canada, hospital for sick children and university of toronto,toronto, Canada, from british columbia children's hospital and university of british columbia,vancouver, Canada, alberta children's hospital and university of calgary,calgary, Canada, iwk health centre and dalhousie university,halifax, Canada, stollery children's hospital and university of alberta,edmonton, Canada, iwk health centre and dalhousie university,halifax, Canada, children's hospital of eastern ontario and university of ottawa,ottawa, Canada, mcgill university health centre and mcgill university,montreal, Canada, alberta children's hospital and university of calgary,calgary, Canada, mcgill university health centre and mcgill university,montreal, Canada, hospital for sick children and university of toronto,toronto, Canada, hospital for sick children and university of toronto,toronto, Canada, department of pediatrics university of british columbia,vancouver, Canada, department of pediatrics university of british columbia,vancouver, Canada, université de montréal,montréal, Canada, hospital for sick children and university of toronto,toronto, Canada, children's hospital of eastern ontario and university of ottawa,ottawa, Canada, centre hospitalier universitaire de laval and université laval,quebec, Canada, mcgill university health centre and mcgill university,montreal, Canada, centre hospitalier universitaire ste. justine and université de montréal,montréal, Canada, children's hospital of eastern ontario and university of ottawa,ottawa, Canada, hospital for sick children and university of toronto,toronto, Canada, children's hospital of eastern ontario and university of ottawa,ottawa, Canada, from british columbia children's hospital and university of british columbia,vancouver, Canada
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|