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The procoagulant effects of fine particulate matter in vivo
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نویسنده
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kilinç e. ,schulz h. ,kuiper g.j.a.j.m. ,spronk h.m.h. ,ten cate h. ,upadhyay s. ,ganguly k. ,stoeger t. ,semmler-bhenke m. ,takenaka s. ,kreyling w.g. ,pitz m. ,reitmeir p. ,peters a. ,eickelberg o. ,wichmann h.e.
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منبع
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particle and fibre toxicology - 2011 - دوره : 8 - شماره : 0
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چکیده
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Inhalation of fine particulate matter (<2.5 μm; fine pm) has been shown to increase the risk for cardiovascular events. in this letter,we reappraise the role of tissue factor (tf) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with fine pm. by considering all studies including ours,we conclude that monitoring the overall coagulation state by measuring capacity assays such as thrombin generation,and quantification of tf activity would be more suitable than determining single coagulation proteins (such as tf antigen) in order to better assess the systemic prothrombotic effects of fine pm. © 2011 kilinç et al; licensee biomed central ltd.
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آدرس
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department of internal medicine,laboratory for clinical thrombosis and haemostasis,cardiovascular research institute maastricht,maastricht university medical center,p.o. box 616,uns 50: box 8,6200 md,maastricht, Netherlands, institute of epidemiology i,helmholtz zentrum münchen,german research center for environmental health,ingolstaedter landstrasse 1,d85764,neuherberg/munich,germany,comprehensive pneumology center,institute of lung biology and disease,helmholtz zentrum münchen,german research center for environmental health,ingolstaedter landstrasse 1,d85764,neuherberg/munich, Germany, department of internal medicine,laboratory for clinical thrombosis and haemostasis,cardiovascular research institute maastricht,maastricht university medical center,p.o. box 616,uns 50: box 8,6200 md,maastricht, Netherlands, department of internal medicine,laboratory for clinical thrombosis and haemostasis,cardiovascular research institute maastricht,maastricht university medical center,p.o. box 616,uns 50: box 8,6200 md,maastricht, Netherlands, department of internal medicine,laboratory for clinical thrombosis and haemostasis,cardiovascular research institute maastricht,maastricht university medical center,p.o. box 616,uns 50: box 8,6200 md,maastricht, Netherlands, department of environmental and occupational health,graduate school of public health,university of pittsburgh,100 technology drive,bridge side point,pittsburgh,15219 pa, United States, department of environmental and occupational health,graduate school of public health,university of pittsburgh,100 technology drive,bridge side point,pittsburgh,15219 pa, United States, comprehensive pneumology center,institute of lung biology and disease,helmholtz zentrum münchen,german research center for environmental health,ingolstaedter landstrasse 1,d85764,neuherberg/munich, Germany, comprehensive pneumology center,institute of lung biology and disease,helmholtz zentrum münchen,german research center for environmental health,ingolstaedter landstrasse 1,d85764,neuherberg/munich, Germany, comprehensive pneumology center,institute of lung biology and disease,helmholtz zentrum münchen,german research center for environmental health,ingolstaedter landstrasse 1,d85764,neuherberg/munich, Germany, comprehensive pneumology center,institute of lung biology and disease,helmholtz zentrum münchen,german research center for environmental health,ingolstaedter landstrasse 1,d85764,neuherberg/munich,germany,focus network nanoparticles and health,helmholtz zentrum münchen,german research center for environmental health,ingolstaedter landstrasse 1,d85764,neuherberg/munich, Germany, institute of epidemiology ii,helmholtz zentrum münchen,german research center for environmental health,ingolstaedter landstrasse 1,d85764,neuherberg/munich, Germany, institute of health economics and health care management,helmholtz zentrum münchen,german research center for environmental health,ingolstaedter landstrasse 1,d85764,neuherberg/munich, Germany, institute of epidemiology ii,helmholtz zentrum münchen,german research center for environmental health,ingolstaedter landstrasse 1,d85764,neuherberg/munich, Germany, comprehensive pneumology center,institute of lung biology and disease,helmholtz zentrum münchen,german research center for environmental health,ingolstaedter landstrasse 1,d85764,neuherberg/munich, Germany, institute of epidemiology i,helmholtz zentrum münchen,german research center for environmental health,ingolstaedter landstrasse 1,d85764,neuherberg/munich,germany,focus network nanoparticles and health,helmholtz zentrum münchen,german research center for environmental health,ingolstaedter landstrasse 1,d85764,neuherberg/munich, Germany
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Authors
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