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Mechanistic understanding of nanoparticles' interactions with extracellular matrix: the cell and immune system
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نویسنده
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engin a.b. ,nikitovic d. ,neagu m. ,henrich-noack p. ,docea a.o. ,shtilman m.i. ,golokhvast k. ,tsatsakis a.m.
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منبع
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particle and fibre toxicology - 2017 - دوره : 14 - شماره : 1
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چکیده
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Extracellular matrix (ecm) is an extraordinarily complex and unique meshwork composed of structural proteins and glycosaminoglycans. the ecm provides essential physical scaffolding for the cellular constituents,as well as contributes to crucial biochemical signaling. importantly,ecm is an indispensable part of all biological barriers and substantially modulates the interchange of the nanotechnology products through these barriers. the interactions of the ecm with nanoparticles (nps) depend on the morphological characteristics of intercellular matrix and on the physical characteristics of the nps and may be either deleterious or beneficial. importantly,an altered expression of ecm molecules ultimately affects all biological processes including inflammation. this review critically discusses the specific behavior of nps that are within the ecm domain,and passing through the biological barriers. furthermore,regenerative and toxicological aspects of nanomaterials are debated in terms of the immune cells-nps interactions. © 2017 the author(s).
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کلیدواژه
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Biological barriers; Extracellular matrix; Inflammation; Nanoparticle
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آدرس
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gazi university,department of toxicology,faculty of pharmacy,hipodrom,ankara,06330, Turkey, university of crete,laboratory of anatomy-histology-embryology,medical school,heraklion, Greece, victor babes national institute of pathology,immunology department,99-101 splaiul independentei,bucharest,050096, Romania, otto-von-guericke university,institute of medical psychology,magdeburg,39120, Germany, university of medicine and pharmacy,faculty of pharmacy,department of toxicology,petru rares,craiova,200349, Romania, d.i. mendeleyev university of chemical technology,master school biomaterials,moscow, Russian Federation, far eastern federal university,scientific educational center nanotechnology,engineering school,vladivostok, Russian Federation, far eastern federal university,scientific educational center nanotechnology,engineering school,vladivostok,russian federation,university of crete,center of toxicology science and research,medical school,heraklion,crete, Greece
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Authors
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