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TLR3 Signaling in Macrophages Is Indispensable for the Protective Immunity of Invariant Natural Killer T Cells against Enterovirus 71 Infection
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نویسنده
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zhu k. ,yang j. ,luo k. ,yang c. ,zhang n. ,xu r. ,chen j. ,jin m. ,xu b. ,guo n. ,wang j. ,chen z. ,cui y. ,zhao h. ,wang y. ,deng c. ,bai l. ,ge b. ,qin c.-f. ,shen h. ,yang c.-f. ,leng q.
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منبع
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plos pathogens - 2015 - دوره : 11 - شماره : 1 - صفحه:1 -19
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چکیده
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Enterovirus 71 (ev71) is the most virulent pathogen among enteroviruses that cause hand,foot and mouth disease in children but rarely in adults. the mechanisms that determine the age-dependent susceptibility remain largely unclear. here,we found that the paucity of invariant natural killer t (inkt) cells together with immaturity of the immune system was related to the susceptibility of neonatal mice to ev71 infection. inkt cells were crucial antiviral effector cells to protect young mice from ev71 infection before their adaptive immune systems were fully mature. ev71 infection led to activation of inkt cells depending on signaling through tlr3 but not other tlrs. surprisingly,inkt cell activation during ev71 infection required tlr3 signaling in macrophages,but not in dendritic cells (dcs). mechanistically,interleukin (il)-12 and endogenous cd1d-restricted antigens were both required for full activation of inkt cells. furthermore,cd1d-deficiency led to dramatically increased viral loads in central nervous system and more severe disease in ev71-infected mice. altogether,our results suggest that inkt cells may be involved in controlling ev71 infection in children when their adaptive immune systems are not fully developed,and also imply that inkt cells might be an intervention target for treating ev71-infected patients. © 2015 zhu et al.
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آدرس
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key laboratory of molecular virology and immunology,institut pasteur of shanghai,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, key laboratory of molecular virology and immunology,institut pasteur of shanghai,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, key laboratory of molecular virology and immunology,institut pasteur of shanghai,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, key laboratory of molecular virology and immunology,institut pasteur of shanghai,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, key laboratory of molecular virology and immunology,institut pasteur of shanghai,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, hefei national laboratory for physical sciences at microscale,innovation center for cell biology,institute of immunology,school of life sciences,university of science and technology of china,hefei, China, department of microbiology and immunology,tongji university school of medicine,shanghai, China, key laboratory of molecular virology and immunology,institut pasteur of shanghai,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, key laboratory of molecular virology and immunology,institut pasteur of shanghai,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, key laboratory of molecular virology and immunology,institut pasteur of shanghai,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, key laboratory of molecular virology and immunology,institut pasteur of shanghai,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, hefei national laboratory for physical sciences at microscale,innovation center for cell biology,institute of immunology,school of life sciences,university of science and technology of china,hefei, China, key laboratory of molecular virology and immunology,institut pasteur of shanghai,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, state key laboratory of pathogen and biosecurity,beijing institute of microbiology and epidemiology,beijing, China, department of microbiology,perelman school of medicine,university of pennsylvania,philadelphia,pa, United States, key laboratory of molecular virology and immunology,institut pasteur of shanghai,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, hefei national laboratory for physical sciences at microscale,innovation center for cell biology,institute of immunology,school of life sciences,university of science and technology of china,hefei, China, department of microbiology and immunology,tongji university school of medicine,shanghai, China, state key laboratory of pathogen and biosecurity,beijing institute of microbiology and epidemiology,beijing, China, department of microbiology,perelman school of medicine,university of pennsylvania,philadelphia,pa, United States, key laboratory of molecular virology and immunology,institut pasteur of shanghai,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, key laboratory of molecular virology and immunology,institut pasteur of shanghai,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China
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Authors
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