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IFNγ Signaling Endows DCs with the Capacity to Control Type I Inflammation during Parasitic Infection through Promoting T-bet+ Regulatory T Cells
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نویسنده
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lee h.-m. ,fleige a. ,forman r. ,cho s. ,khan a.a. ,lin l.-l. ,nguyen d.t. ,o'hara-hall a. ,yin z. ,hunter c.a. ,muller w. ,lu l.-f.
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منبع
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plos pathogens - 2015 - دوره : 11 - شماره : 2
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چکیده
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Ifnγ signaling drives dendritic cells (dcs) to promote type i t cell (th1) immunity. here,we show that activation of dcs by ifnγ is equally crucial for the differentiation of a population of t-bet+ regulatory t (treg) cells specialized to inhibit th1 immune responses. conditional deletion of ifnγ receptor in dcs but not in treg cells resulted in a severe defect in this specific treg cell subset,leading to exacerbated immune pathology during parasitic infections. mechanistically,ifnγ-unresponsive dcs failed to produce sufficient amount of il-27,a cytokine required for optimal t-bet induction in treg cells. thus,ifnγ signalling endows dcs with the ability to efficiently control a specific type of t cell immunity through promoting a corresponding treg cell population. © 2015 lee et al.
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آدرس
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division of biological sciences,university of california,san diego,la jolla,ca, United States, technical university braunschweig,braunschweig, Germany, university of manchester,manchester, United Kingdom, division of biological sciences,university of california,san diego,la jolla,ca, United States, department of human genetics,institute for genomics and systems biology,university of chicago,chicago,il, United States, division of biological sciences,university of california,san diego,la jolla,ca, United States, division of biological sciences,university of california,san diego,la jolla,ca, United States, department of pathobiology,school of veterinary medicine,university of pennsylvania,philadelphia,pa, United States, the first affiliated hospital,international imunology center,the biomedical translational research institute,key laboratory of molecular immunology and antibody engineering of guangdong province,jinan university,guangzhou,guangdong, China, department of pathobiology,school of veterinary medicine,university of pennsylvania,philadelphia,pa, United States, university of manchester,manchester, United Kingdom, division of biological sciences,university of california,san diego,la jolla,ca,united states,moores cancer center,university of california,san diego,la jolla,ca, United States
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Authors
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