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A Rho GDP Dissociation Inhibitor Produced by Apoptotic T-Cells Inhibits Growth of Mycobacterium tuberculosis
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نویسنده
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venkatasubramanian s. ,dhiman r. ,paidipally p. ,cheekatla s.s. ,tripathi d. ,welch e. ,tvinnereim a.r. ,jones b. ,theodorescu d. ,barnes p.f. ,vankayalapati r.
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منبع
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plos pathogens - 2015 - دوره : 11 - شماره : 2
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چکیده
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In this study,we found that a subpopulation of cd4+cd25+ (85% foxp3+) cells from persons with latent tuberculosis infection (ltbi) inhibits growth of m. tuberculosis (m. tb) in human monocyte-derived macrophages (mdms). a soluble factor,rho gdp dissociation inhibitor (d4gdi),produced by apoptotic cd4+cd25+ (85% foxp3+) cells is responsible for this inhibition of m. tb growth in human macrophages and in mice. m. tb-expanded cd4+cd25+foxp3+d4gdi+ cells do not produce il-10,tgf-β and ifn-γ. d4gdi inhibited growth of m. tb in mdms by enhancing production of il-1β,tnf-α and ros,and by increasing apoptosis of m. tb-infected mdms. d4gdi was concentrated at the site of disease in tuberculosis patients,with higher levels detected in pleural fluid than in serum. however,in response to m. tb,pbmc from tuberculosis patients produced less d4gdi than pbmc from persons with ltbi. m. tb-expanded cd4+cd25+ (85% foxp3+) cells and d4gdi induced intracellular m. tb to express the dormancy survival regulator dosr and dosr-dependent genes,suggesting that d4gdi induces a non-replicating state in the pathogen. our study provides the first evidence that a subpopulation of cd4+cd25+ (85% foxp3+) cells enhances immunity to m. tb,and that production of d4gdi by this subpopulation inhibits m. tb growth. © 2015 venkatasubramanian et al.
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آدرس
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department of pulmonary immunology,center for biomedical research,university of texas health center,tyler,tx, United States, department of pulmonary immunology,center for biomedical research,university of texas health center,tyler,tx,united states,department of life science,national institute of technology,rourkela,odisha, India, department of pulmonary immunology,center for biomedical research,university of texas health center,tyler,tx, United States, department of pulmonary immunology,center for biomedical research,university of texas health center,tyler,tx, United States, department of pulmonary immunology,center for biomedical research,university of texas health center,tyler,tx, United States, department of pulmonary immunology,center for biomedical research,university of texas health center,tyler,tx, United States, department of pulmonary immunology,center for biomedical research,university of texas health center,tyler,tx, United States, keck school of medicine,university of southern california,los angeles,ca, United States, university of colorado comprehensive cancer center,aurora,co, United States, department of pulmonary immunology,center for biomedical research,university of texas health center,tyler,tx, United States, department of pulmonary immunology,center for biomedical research,university of texas health center,tyler,tx, United States
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Authors
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