|
|
|
|
FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure
|
|
|
|
|
|
|
|
نویسنده
|
sullivan r.t. ,kim c.c. ,fontana m.f. ,feeney m.e. ,jagannathan p. ,boyle m.j. ,drakeley c.j. ,ssewanyana i. ,nankya f. ,mayanja-kizza h. ,dorsey g. ,greenhouse b.
|
|
منبع
|
plos pathogens - 2015 - دوره : 11 - شماره : 5
|
|
چکیده
|
Exposure to plasmodium falciparum is associated with circulating “atypical” memory b cells (atmbcs),which appear similar to dysfunctional b cells found in hiv-infected individuals. functional analysis of atmbcs has been limited,with one report suggesting these cells are not dysfunctional but produce protective antibodies. to better understand the function of malaria-associated atmbcs,we performed global transcriptome analysis of these cells,obtained from individuals living in an area of high malaria endemicity in uganda. comparison of gene expression data suggested down-modulation of b cell receptor signaling and apoptosis in atmbcs compared to classical mbcs. additionally,in contrast to previous reports,we found upregulation of fc receptor-like 5 (fcrl5),but not fcrl4,on atmbcs. atypical mbcs were poor spontaneous producers of antibody ex vivo,and higher surface expression of fcrl5 defined a distinct subset of atmbcs compromised in its ability to produce antibody upon stimulation. moreover,higher levels of p. falciparum exposure were associated with increased frequencies of fcrl5+ atmbcs. together,our findings suggest that fclr5+ identifies a functionally distinct,and perhaps dysfunctional,subset of mbcs in individuals exposed to p. falciparum. © 2015 sullivan et al.
|
|
|
|
|
آدرس
|
division of infectious diseases,department of medicine,university of california,san francisco,san francisco,ca, United States, division of experimental medicine,department of medicine,university of california,san francisco,san francisco,ca, United States, division of experimental medicine,department of medicine,university of california,san francisco,san francisco,ca, United States, division of experimental medicine,department of medicine,university of california,san francisco,san francisco,ca, United States, division of hiv/aids,department of medicine,university of california,san francisco,san francisco,ca, United States, division of experimental medicine,department of medicine,university of california,san francisco,san francisco,ca,united states,center for biomedical research,the burnet institute,melbourne, Australia, department of immunology and infection,london school of hygiene and tropical medicine,london, United Kingdom, department of immunology and infection,london school of hygiene and tropical medicine,london,united kingdom,infectious disease research collaboration, Uganda, infectious disease research collaboration, Uganda, infectious disease research collaboration,uganda,infectious diseases institute,makerere university college of health sciences,kampala, Uganda, division of infectious diseases,department of medicine,university of california,san francisco,san francisco,ca, United States, division of infectious diseases,department of medicine,university of california,san francisco,san francisco,ca, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|