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ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs
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نویسنده
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chen w. ,li s. ,yu h. ,liu x. ,huang l. ,wang q. ,liu h. ,cui y. ,tang y. ,zhang p. ,wang c.
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منبع
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plos pathogens - 2016 - دوره : 12 - شماره : 2
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چکیده
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Stimulator of interferon genes (sting,also known as mita,eris or mpys) induces the activation of tbk1 kinase and irf3 transcription factor,upon sensing of microbial dnas. how irf3 is recruited onto the sting signalosome remains unknown. we report here that silencing of the er adaptor scap markedly impairs the irf3-responsive gene expression induced by sting. scap knockdown mice are more susceptible to hsv-1 infection. interestingly,scap translocates from er,via golgi,to perinuclear microsome in a sting-dependent manner. mechanistically,the n-terminal transmembrane domain of scap interacts with sting,and the c-terminal cytosolic domain of scap binds to irf3,thus recruiting irf3 onto sting signalosome. mis-localization of scap abolishes its antiviral function. collectively,this study characterizes scap as an essential adaptor in the sting signaling pathway,uncovering a critical missing link in dnas-triggered host antiviral responses. © 2016 chen et al.
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آدرس
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state key laboratory of cell biology,cas center for excellence in molecular cell science,innovation center for cell signaling network,institute of biochemistry and cell biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai,china,key laboratory of medical reprogramming technology,shenzhen second people’s hospital,first affiliated hospital of shenzhen university,shenzhen, China, state key laboratory of cell biology,cas center for excellence in molecular cell science,innovation center for cell signaling network,institute of biochemistry and cell biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, state key laboratory of cell biology,cas center for excellence in molecular cell science,innovation center for cell signaling network,institute of biochemistry and cell biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, state key laboratory of cell biology,cas center for excellence in molecular cell science,innovation center for cell signaling network,institute of biochemistry and cell biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, state key laboratory of cell biology,cas center for excellence in molecular cell science,innovation center for cell signaling network,institute of biochemistry and cell biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, state key laboratory of cell biology,cas center for excellence in molecular cell science,innovation center for cell signaling network,institute of biochemistry and cell biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, state key laboratory of cell biology,cas center for excellence in molecular cell science,innovation center for cell signaling network,institute of biochemistry and cell biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, state key laboratory of cell biology,cas center for excellence in molecular cell science,innovation center for cell signaling network,institute of biochemistry and cell biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, state key laboratory of cell biology,cas center for excellence in molecular cell science,innovation center for cell signaling network,institute of biochemistry and cell biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China, department of thoracic surgery,shanghai pulmonary hospital,tongji university,school of medicine,shanghai, China, state key laboratory of cell biology,cas center for excellence in molecular cell science,innovation center for cell signaling network,institute of biochemistry and cell biology,shanghai institutes for biological sciences,chinese academy of sciences,shanghai, China
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Authors
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