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Genomic Modifiers of Natural Killer Cells,Immune Responsiveness and Lymphoid Tissue Remodeling Together Increase Host Resistance to Viral Infection
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نویسنده
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gillespie a.l. ,teoh j. ,lee h. ,prince j. ,stadnisky m.d. ,anderson m. ,nash w. ,rival c. ,wei h. ,gamache a. ,farber c.r. ,tung k. ,brown m.g.
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منبع
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plos pathogens - 2016 - دوره : 12 - شماره : 2
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چکیده
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The mhc class i dk molecule supplies vital host resistance during murine cytomegalovirus (mcmv) infection. natural killer (nk) cells expressing the ly49g2 inhibitory receptor,which specifically binds dk,are required to control viral spread. the extent of dk-dependent host resistance,however,differs significantly amongst related strains of mice,c57l and ma/my. as a result,we predicted that relatively small-effect modifier genetic loci might together shape immune cell features,nk cell reactivity,and the host immune response to mcmv. a robust dk-dependent genetic effect,however,has so far hindered attempts to identify additional host resistance factors. thus,we applied genomic mapping strategies and multicolor flow cytometric analysis of immune cells in naive and virus-infected hosts to identify genetic modifiers of the host immune response to mcmv. we discovered and validated many quantitative trait loci (qtl); these were mapped to at least 19 positions on 16 chromosomes. intriguingly,one newly discovered non-mhc locus (cmv5) controlled splenic nk cell accrual,secondary lymphoid organ structure,and lymphoid follicle development during mcmv infection. we infer that cmv5 aids host resistance to mcmv infection by expanding nk cells needed to preserve and protect essential tissue structural elements,to enhance lymphoid remodeling and to increase viral clearance in spleen. © 2016 gillespie et al.
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آدرس
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department of medicine,division of nephrology,university of virginia,charlottesville,va,united states,beirne carter center for immunology research,university of virginia,charlottesville,va, United States, beirne carter center for immunology research,university of virginia,charlottesville,va,united states,department of microbiology,immunology and cancer biology,university of virginia,charlottesville,va, United States, department of biology,university of virginia,charlottesville,va, United States, department of medicine,division of nephrology,university of virginia,charlottesville,va,united states,beirne carter center for immunology research,university of virginia,charlottesville,va, United States, beirne carter center for immunology research,university of virginia,charlottesville,va,united states,department of microbiology,immunology and cancer biology,university of virginia,charlottesville,va,united states,flowjo,llc,ashland,or, United States, department of pathology,university of virginia,charlottesville,va, United States, beirne carter center for immunology research,university of virginia,charlottesville,va,united states,department of microbiology,immunology and cancer biology,university of virginia,charlottesville,va, United States, beirne carter center for immunology research,university of virginia,charlottesville,va,united states,department of pathology,university of virginia,charlottesville,va, United States, department of medicine,division of nephrology,university of virginia,charlottesville,va,united states,beirne carter center for immunology research,university of virginia,charlottesville,va, United States, beirne carter center for immunology research,university of virginia,charlottesville,va,united states,department of microbiology,immunology and cancer biology,university of virginia,charlottesville,va, United States, department of biochemistry and molecular genetics,university of virginia,charlottesville,va,united states,department of public health sciences,university of virginia,charlottesville,va,united states,center for public health genomics,university of virginia,charlottesville,va, United States, beirne carter center for immunology research,university of virginia,charlottesville,va,united states,department of pathology,university of virginia,charlottesville,va, United States, department of medicine,division of nephrology,university of virginia,charlottesville,va,united states,beirne carter center for immunology research,university of virginia,charlottesville,va,united states,department of microbiology,immunology and cancer biology,university of virginia,charlottesville,va, United States
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Authors
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