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The E3 Ligase APIP10 Connects the Effector AvrPiz-t to the NLR Receptor Piz-t in Rice
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نویسنده
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park c.h. ,shirsekar g. ,bellizzi m. ,chen s. ,songkumarn p. ,xie x. ,shi x. ,ning y. ,zhou b. ,suttiviriya p. ,wang m. ,umemura k. ,wang g.-l.
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منبع
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plos pathogens - 2016 - دوره : 12 - شماره : 3
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چکیده
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Although nucleotide-binding domain,leucine-rich repeat (nlr) proteins are the major immune receptors in plants,the mechanism that controls their activation and immune signaling remains elusive. here,we report that the avirulence effector avrpiz-t from magnaporthe oryzae targets the rice e3 ligase apip10 for degradation,but that apip10,in return,ubiquitinates avrpiz-t and thereby causes its degradation. silencing of apip10 in the non-piz-t background compromises the basal defense against m. oryzae. conversely,silencing of apip10 in the piz-t background causes cell death,significant accumulation of piz-t,and enhanced resistance to m. oryzae,suggesting that apip10 is a negative regulator of piz-t. we show that apip10 promotes degradation of piz-t via the 26s proteasome system. furthermore,we demonstrate that avrpiz-t stabilizes piz-t during m. oryzae infection. together,our results show that apip10 is a novel e3 ligase that functionally connects the fungal effector avrpiz-t to its nlr receptor piz-t in rice. © 2016 park et al.
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آدرس
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department of plant pathology,ohio state university,columbus,oh,united states,state laboratory for biology of plant diseases and insect pests,institute of plant protection,chinese academy of agricultural sciences,beijing, China, department of plant pathology,ohio state university,columbus,oh, United States, department of plant pathology,ohio state university,columbus,oh, United States, department of plant pathology,ohio state university,columbus,oh,united states,biotechnology research institute,fujian academy of agricultural sciences,fuzhou,fujian, China, department of plant pathology,ohio state university,columbus,oh, United States, state laboratory for biology of plant diseases and insect pests,institute of plant protection,chinese academy of agricultural sciences,beijing, China, state laboratory for biology of plant diseases and insect pests,institute of plant protection,chinese academy of agricultural sciences,beijing, China, state laboratory for biology of plant diseases and insect pests,institute of plant protection,chinese academy of agricultural sciences,beijing, China, department of plant pathology,ohio state university,columbus,oh, United States, department of plant pathology,ohio state university,columbus,oh, United States, department of plant pathology,ohio state university,columbus,oh, United States, meiji seika kaisha ltd,health & bioscience laboratories,tokyo, Japan, department of plant pathology,ohio state university,columbus,oh,united states,state laboratory for biology of plant diseases and insect pests,institute of plant protection,chinese academy of agricultural sciences,beijing, China
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Authors
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