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Nipah Virus C Protein Recruits Tsg101 to Promote the Efficient Release of Virus in an ESCRT-Dependent Pathway
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نویسنده
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park a. ,yun t. ,vigant f. ,pernet o. ,won s.t. ,dawes b.e. ,bartkowski w. ,freiberg a.n. ,lee b.
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منبع
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plos pathogens - 2016 - دوره : 12 - شماره : 5
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چکیده
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The budding of nipah virus,a deadly member of the henipavirus genus within the paramyxoviridae,has been thought to be independent of the host escrt pathway,which is critical for the budding of many enveloped viruses. this conclusion was based on the budding properties of the virus matrix protein in the absence of other virus components. here,we find that the virus c protein,which was previously investigated for its role in antagonism of innate immunity,recruits the escrt pathway to promote efficient virus release. inhibition of escrt or depletion of the escrt factor tsg101 abrogates the c enhancement of matrix budding and impairs live nipah virus release. further,despite the low sequence homology of the c proteins of known henipaviruses,they all enhance the budding of their cognate matrix proteins,suggesting a conserved and previously unknown function for the henipavirus c proteins. © 2016 park et al.
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آدرس
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department of microbiology,immunology and molecular genetics,david geffen school of medicine at the university of california-los angeles,los angeles,ca,united states,department of microbiology,icahn school of medicine at mount sinai,new york,ny, United States, department of pathology,university of texas medical branch,galveston,tx, United States, department of microbiology,icahn school of medicine at mount sinai,new york,ny, United States, department of microbiology,immunology and molecular genetics,david geffen school of medicine at the university of california-los angeles,los angeles,ca, United States, department of microbiology,icahn school of medicine at mount sinai,new york,ny, United States, department of pathology,university of texas medical branch,galveston,tx, United States, department of microbiology,immunology and molecular genetics,david geffen school of medicine at the university of california-los angeles,los angeles,ca, United States, department of pathology,university of texas medical branch,galveston,tx,united states,center for biodefense and emerging infectious diseases,university of texas medical branch,galveston,tx,united states,institute for human infections and immunity,university of texas medical branch,galveston,tx, United States, department of microbiology,immunology and molecular genetics,david geffen school of medicine at the university of california-los angeles,los angeles,ca,united states,department of microbiology,icahn school of medicine at mount sinai,new york,ny, United States
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Authors
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