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Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons
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نویسنده
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deriu e. ,boxx g.m. ,he x. ,pan c. ,benavidez s.d. ,cen l. ,rozengurt n. ,shi w. ,cheng g.
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منبع
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plos pathogens - 2016 - دوره : 12 - شماره : 5
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چکیده
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Human influenza viruses replicate almost exclusively in the respiratory tract,yet infected individuals may also develop gastrointestinal symptoms,such as vomiting and diarrhea. however,the molecular mechanisms remain incompletely defined. using an influenza mouse model,we found that influenza pulmonary infection can significantly alter the intestinal microbiota profile through a mechanism dependent on type i interferons (ifn-is). notably,influenza-induced ifn-is produced in the lungs promote the depletion of obligate anaerobic bacteria and the enrichment of proteobacteria in the gut,leading to a “dysbiotic” microenvironment. additionally,we provide evidence that ifn-is induced in the lungs during influenza pulmonary infection inhibit the antimicrobial and inflammatory responses in the gut during salmonella-induced colitis,further enhancing salmonella intestinal colonization and systemic dissemination. thus,our studies demonstrate a systemic role for ifn-is in regulating the host immune response in the gut during salmonella-induced colitis and in altering the intestinal microbial balance after influenza infection. © 2016 deriu et al.
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آدرس
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department of microbiology,immunology and molecular genetics,university of california,los angeles,los angeles,ca, United States, department of microbiology,immunology and molecular genetics,university of california,los angeles,los angeles,ca, United States, school of dentistry,university of california,los angeles,los angeles,ca, United States, department of human genetics,university of california,los angeles,los angeles,ca, United States, department of microbiology,immunology and molecular genetics,university of california,los angeles,los angeles,ca, United States, school of dentistry,university of california,los angeles,los angeles,ca, United States, department of pathology and laboratory medicine,cure imaging and stem cell biology core,university of california,los angeles,los angeles,ca, United States, school of dentistry,university of california,los angeles,los angeles,ca, United States, department of microbiology,immunology and molecular genetics,university of california,los angeles,los angeles,ca, United States
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Authors
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