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Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation
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نویسنده
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abdel-mohsen m. ,chavez l. ,tandon r. ,chew g.m. ,deng x. ,danesh a. ,keating s. ,lanteri m. ,samuels m.l. ,hoh r. ,sacha j.b. ,norris p.j. ,niki t. ,shikuma c.m. ,hirashima m. ,deeks s.g. ,ndhlovu l.c. ,pillai s.k.
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منبع
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plos pathogens - 2016 - دوره : 12 - شماره : 6
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چکیده
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Identifying host immune determinants governing hiv transcription,latency and infectivity in vivo is critical to developing an hiv cure. based on our recent finding that the host factor p21 regulates hiv transcription during antiretroviral therapy (art),and published data demonstrating that the human carbohydrate-binding immunomodulatory protein galectin-9 regulates p21,we hypothesized that galectin-9 modulates hiv transcription. we report that the administration of a recombinant,stable form of galectin-9 (rgal-9) potently reverses hiv latency in vitro in the j-lat hiv latency model. furthermore,rgal-9 reverses hiv latency ex vivo in primary cd4+ t cells from hiv-infected,art-suppressed individuals (p = 0.002),more potently than vorinostat (p = 0.02). rgal-9 co-administration with the latency reversal agent jq1
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کلیدواژه
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a bromodomain inhibitor
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آدرس
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blood systems research institute,san francisco,ca,united states,university of california,san francisco,ca, United States, blood systems research institute,san francisco,ca, United States, school of biotechnology,jawaharlal nehru university,new delhi, India, hawaii center for aids,john a. burns school of medicine,university of hawaii,honolulu,hi, United States, blood systems research institute,san francisco,ca, United States, blood systems research institute,san francisco,ca,united states,university of california,san francisco,ca, United States, blood systems research institute,san francisco,ca, United States, blood systems research institute,san francisco,ca, United States, raindance technologies,inc.,billerica,ma, United States, university of california,san francisco,ca, United States, vaccine & gene therapy institute,oregon health & science university,portland,or,united states,oregon national primate research center,oregon health & science university,portland,or, United States, blood systems research institute,san francisco,ca,united states,university of california,san francisco,ca, United States, galpharma co.,ltd.,takamatsu-shi,kagawa,japan,department of immunology and immunopathology,kagawa university,kagawa, Japan, hawaii center for aids,john a. burns school of medicine,university of hawaii,honolulu,hi, United States, galpharma co.,ltd.,takamatsu-shi,kagawa,japan,department of immunology and immunopathology,kagawa university,kagawa, Japan, university of california,san francisco,ca, United States, hawaii center for aids,john a. burns school of medicine,university of hawaii,honolulu,hi, United States, blood systems research institute,san francisco,ca,united states,university of california,san francisco,ca, United States
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Authors
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