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Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females
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نویسنده
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hall o.j. ,limjunyawong n. ,vermillion m.s. ,robinson d.p. ,wohlgemuth n. ,pekosz a. ,mitzner w. ,klein s.l.
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منبع
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plos pathogens - 2016 - دوره : 12 - شماره : 9
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چکیده
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Over 100 million women use progesterone therapies worldwide. despite having immunomodulatory and repair properties,their effects on the outcome of viral diseases outside of the reproductive tract have not been evaluated. administration of exogenous progesterone (at concentrations that mimic the luteal phase) to progesterone-depleted adult female mice conferred protection from both lethal and sublethal influenza a virus (iav) infection. progesterone treatment altered the inflammatory environment of the lungs,but had no effects on viral load. progesterone treatment promoted faster recovery by increasing tgf-β,il-6,il-22,numbers of regulatory th17 cells expressing cd39,and cellular proliferation,reducing protein leakage into the airway,improving pulmonary function,and upregulating the epidermal growth factor amphiregulin (areg) in the lungs. administration of rareg to progesterone-depleted females promoted pulmonary repair and improved the outcome of iav infection. progesterone-treatment of areg-deficient females could not restore protection,indicating that progesterone-mediated induction of areg caused repair in the lungs and accelerated recovery from iav infection. repair and production of areg by damaged respiratory epithelial cell cultures in vitro was increased by progesterone. our results illustrate that progesterone is a critical host factor mediating production of areg by epithelial cells and pulmonary tissue repair following infection,which has important implications for women’s health. © 2016 hall et al.
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آدرس
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w. harry feinstone department of molecular microbiology and immunology,the johns hopkins bloomberg school of public health,baltimore,md, United States, department of environmental health sciences,the johns hopkins bloomberg school of public health,baltimore,md,united states,nathachit limjunyawong,the solomon h. snyder department of neuroscience,the johns hopkins school of medicine,baltimore,md, United States, w. harry feinstone department of molecular microbiology and immunology,the johns hopkins bloomberg school of public health,baltimore,md,united states,department of molecular and comparative pathobiology,the johns hopkins university school of medicine,baltimore,md, United States, w. harry feinstone department of molecular microbiology and immunology,the johns hopkins bloomberg school of public health,baltimore,md,united states,dionne p. robinson,laboratory of parasitic diseases,national institutes of health,niaid,bethesda,md, United States, w. harry feinstone department of molecular microbiology and immunology,the johns hopkins bloomberg school of public health,baltimore,md, United States, w. harry feinstone department of molecular microbiology and immunology,the johns hopkins bloomberg school of public health,baltimore,md,united states,department of environmental health sciences,the johns hopkins bloomberg school of public health,baltimore,md, United States, department of environmental health sciences,the johns hopkins bloomberg school of public health,baltimore,md, United States, w. harry feinstone department of molecular microbiology and immunology,the johns hopkins bloomberg school of public health,baltimore,md,united states,department of biochemistry and molecular biology,the johns hopkins bloomberg school of public health,baltimore,md, United States
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Authors
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