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Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals
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نویسنده
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qi q. ,cavanagh m.m. ,le saux s. ,wagar l.e. ,mackey s. ,hu j. ,maecker h. ,swan g.e. ,davis m.m. ,dekker c.l. ,tian l. ,weyand c.m. ,goronzy j.j.
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منبع
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plos pathogens - 2016 - دوره : 12 - شماره : 10
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چکیده
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Vaccination with attenuated live varicella zoster virus (vzv) can prevent zoster reactivation,but protection is incomplete especially in an older population. to decipher the molecular mechanisms underlying variable vaccine responses,t- and b-cell responses to vzv vaccination were examined in individuals of different ages including identical twin pairs. contrary to the induction of vzv-specific antibodies,antigen-specific t cell responses were significantly influenced by inherited factors. diminished generation of long-lived memory t cells in older individuals was mainly caused by increased t cell loss after the peak response while the expansion of antigen-specific t cells was not affected by age. gene expression in activated cd4 t cells at the time of the peak response identified gene modules related to cell cycle regulation and dna repair that correlated with the contraction phase of the t cell response and consequently the generation of long-lived memory cells. these data identify cell cycle regulatory mechanisms as targets to reduce t cell attrition in a vaccine response and to improve the generation of antigen-specific t cell memory,in particular in an older population. © 2016 public library of science. all rights reserved.
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آدرس
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department of medicine,division of immunology and rheumatology,stanford university,stanford,ca,united states,department of medicine,vapahcs,palo alto,ca, United States, department of medicine,division of immunology and rheumatology,stanford university,stanford,ca,united states,department of medicine,vapahcs,palo alto,ca, United States, department of medicine,division of immunology and rheumatology,stanford university,stanford,ca,united states,department of medicine,vapahcs,palo alto,ca, United States, institute for immunity,transplantation,and infection,stanford university,stanford,ca, United States, department of pediatrics-infectious diseases,stanford university,stanford,ca, United States, department of medicine,division of immunology and rheumatology,stanford university,stanford,ca,united states,department of medicine,vapahcs,palo alto,ca, United States, institute for immunity,transplantation,and infection,stanford university,stanford,ca, United States, department of medicine,stanford prevention research center,stanford university,stanford,ca, United States, institute for immunity,transplantation,and infection,stanford university,stanford,ca, United States, department of pediatrics-infectious diseases,stanford university,stanford,ca, United States, department of biomedical data science,stanford university,stanford,ca, United States, department of medicine,division of immunology and rheumatology,stanford university,stanford,ca,united states,department of medicine,vapahcs,palo alto,ca, United States, department of medicine,division of immunology and rheumatology,stanford university,stanford,ca,united states,department of medicine,vapahcs,palo alto,ca, United States
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Authors
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