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A Mouse Model of Chronic West Nile Virus Disease
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نویسنده
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graham j.b. ,swarts j.l. ,wilkins c. ,thomas s. ,green r. ,sekine a. ,voss k.m. ,ireton r.c. ,mooney m. ,choonoo g. ,miller d.r. ,treuting p.m. ,pardo manuel de villena f. ,ferris m.t. ,mcweeney s. ,gale m. ,lund j.m.
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منبع
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plos pathogens - 2016 - دوره : 12 - شماره : 11
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چکیده
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Infection with west nile virus (wnv) leads to a range of disease outcomes,including chronic infection,though lack of a robust mouse model of chronic wnv infection has precluded identification of the immune events contributing to persistent infection. using the collaborative cross,a population of recombinant inbred mouse strains with high levels of standing genetic variation,we have identified a mouse model of persistent wnv disease,with persistence of viral loads within the brain. compared to lines exhibiting no disease or marked disease,the f1 cross cc(032x013)f1 displays a strong immunoregulatory signature upon infection that correlates with restraint of the wnv-directed cytolytic response. we hypothesize that this regulatory t cell response sufficiently restrains the immune response such that a chronic infection can be maintained in the cns. use of this new mouse model of chronic neuroinvasive virus will be critical in developing improved strategies to prevent prolonged disease in humans. © 2016 graham et al.
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آدرس
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vaccine and infectious disease division,fred hutchinson cancer research center,seattle,wa, United States, vaccine and infectious disease division,fred hutchinson cancer research center,seattle,wa, United States, center for innate immunity and immune disease,department of immunology,university of washington school of medicine,seattle,wa, United States, center for innate immunity and immune disease,department of immunology,university of washington school of medicine,seattle,wa, United States, center for innate immunity and immune disease,department of immunology,university of washington school of medicine,seattle,wa, United States, center for innate immunity and immune disease,department of immunology,university of washington school of medicine,seattle,wa, United States, center for innate immunity and immune disease,department of immunology,university of washington school of medicine,seattle,wa, United States, center for innate immunity and immune disease,department of immunology,university of washington school of medicine,seattle,wa, United States, division of bioinformatics & computational biology,department of medical informatics & clinical epidemiology,oregon health & science university,portland,or,united states,ohsu knight cancer center institute,oregon health & science university,portland,or, United States, division of bioinformatics & computational biology,department of medical informatics & clinical epidemiology,oregon health & science university,portland,or,united states,ohsu knight cancer center institute,oregon health & science university,portland,or, United States, lineberger comprehensive cancer center,department of genetics,university of north carolina at chapel hill,chapel hill,nc, United States, department of comparative medicine,university of washington,seattle,wa, United States, lineberger comprehensive cancer center,department of genetics,university of north carolina at chapel hill,chapel hill,nc, United States, lineberger comprehensive cancer center,department of genetics,university of north carolina at chapel hill,chapel hill,nc, United States, division of bioinformatics & computational biology,department of medical informatics & clinical epidemiology,oregon health & science university,portland,or,united states,ohsu knight cancer center institute,oregon health & science university,portland,or,united states,oregon clinical and translational research institute,oregon health & science university,portland,or, United States, jr.,center for innate immunity and immune disease,department of immunology,university of washington school of medicine,seattle,wa, United States, vaccine and infectious disease division,fred hutchinson cancer research center,seattle,wa,united states,department of global health,university of washington,seattle,wa, United States
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Authors
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