|
|
|
|
Three mutations switch H7N9 influenza to human-type receptor specificity
|
|
|
|
|
|
|
|
نویسنده
|
de vries r.p. ,peng w. ,grant o.c. ,thompson a.j. ,zhu x. ,bouwman k.m. ,de la pena a.t.t. ,van breemen m.j. ,ambepitiya wickramasinghe i.n. ,de haan c.a.m. ,yu w. ,mcbride r. ,sanders r.w. ,woods r.j. ,verheije m.h. ,wilson i.a. ,paulson j.c.
|
|
منبع
|
plos pathogens - 2017 - دوره : 13 - شماره : 6
|
|
چکیده
|
The avian h7n9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infected poultry. the majority of human h7n9 isolates contained a hemagglutinin (ha) mutation (q226l) that has previously been associated with a switch in receptor specificity from avian-type (neuacα2-3gal) to human-type (neuacα2-6gal),as documented for the avian progenitors of the 1957 (h2n2) and 1968 (h3n2) human influenza pandemic viruses. while this raised concern that the h7n9 virus was adapting to humans,the mutation was not sufficient to switch the receptor specificity of h7n9,and has not resulted in sustained transmission in humans. to determine if the h7 ha was capable of acquiring human-type receptor specificity,we conducted mutation analyses. remarkably,three amino acid mutations conferred a switch in specificity for human-type receptors that resembled the specificity of the 2009 human h1 pandemic virus,and promoted binding to human trachea epithelial cells. © 2017 de vries et al.
|
|
|
|
|
آدرس
|
departments of molecular medicine,& immunology and microbiology,the scripps research institute,la jolla,ca,united states,department of chemical biology and drug discovery,utrecht institute for pharmaceutical sciences,utrecht university,cg utrecht, Netherlands, departments of molecular medicine,& immunology and microbiology,the scripps research institute,la jolla,ca, United States, complex carbohydrate research center,university of georgia,athens,ga, United States, departments of molecular medicine,& immunology and microbiology,the scripps research institute,la jolla,ca, United States, department of integrative structural and computational biology,the scripps research institute,la jolla,ca, United States, pathology division,department of pathobiology,faculty of veterinary medicine,utrecht university,yalelaan 1,cl utrecht, Netherlands, department of medical microbiology,academic medical center,university of amsterdam,az amsterdam, Netherlands, department of medical microbiology,academic medical center,university of amsterdam,az amsterdam, Netherlands, pathology division,department of pathobiology,faculty of veterinary medicine,utrecht university,yalelaan 1,cl utrecht, Netherlands, virology division,department of infectious diseases & immunology,faculty of veterinary medicine,utrecht university,yalelaan 1,cl utrecht, Netherlands, department of integrative structural and computational biology,the scripps research institute,la jolla,ca, United States, departments of molecular medicine,& immunology and microbiology,the scripps research institute,la jolla,ca, United States, department of medical microbiology,academic medical center,university of amsterdam,az amsterdam,netherlands,department of microbiology and immunology,weil medical college of cornell university,new york,ny, United States, complex carbohydrate research center,university of georgia,athens,ga, United States, pathology division,department of pathobiology,faculty of veterinary medicine,utrecht university,yalelaan 1,cl utrecht, Netherlands, department of integrative structural and computational biology,the scripps research institute,la jolla,ca,united states,skaggs institute for chemical biology,the scripps research institute,la jolla,ca, United States, departments of molecular medicine,& immunology and microbiology,the scripps research institute,la jolla,ca, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|