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Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis
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نویسنده
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faber f. ,thiennimitr p. ,spiga l. ,byndloss m.x. ,litvak y. ,lawhon s. ,andrews-polymenis h.l. ,winter s.e. ,bäumler a.j.
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منبع
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plos pathogens - 2017 - دوره : 13 - شماره : 1
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چکیده
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Intestinal inflammation caused by salmonella enterica serovar typhimurium increases the availability of electron acceptors that fuel a respiratory growth of the pathogen in the intestinal lumen. here we show that one of the carbon sources driving this respiratory expansion in the mouse model is 1,2-propanediol,a microbial fermentation product. 1,2-propanediol utilization required intestinal inflammation induced by virulence factors of the pathogen. s. typhimurium used both aerobic and anaerobic respiration to consume 1,2-propanediol and expand in the murine large intestine. 1,2-propanediol-utilization did not confer a benefit in germ-free mice,but the pdu genes conferred a fitness advantage upon s. typhimurium in mice mono-associated with bacteroides fragilis or bacteroides thetaiotaomicron. collectively,our data suggest that intestinal inflammation enables s. typhimurium to sidestep nutritional competition by respiring a microbiota-derived fermentation product. © 2017 faber et al.
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آدرس
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department of medial microbiology and immunology,school of medicine,university of california davis,davis,ca, United States, department of microbiology,faculty of medicine,chiang mai university,chiang mai, Thailand, department of microbiology,university of texas southwestern medical center,dallas,tx, United States, department of medial microbiology and immunology,school of medicine,university of california davis,davis,ca, United States, department of medial microbiology and immunology,school of medicine,university of california davis,davis,ca, United States, department of veterinary pathobiology,college of veterinary medicine,texas a&m university,college station,tx, United States, department of microbial pathogenesis and immunology,college of medicine,texas a&m university health science center,bryan,tx, United States, department of microbiology,university of texas southwestern medical center,dallas,tx, United States, department of medial microbiology and immunology,school of medicine,university of california davis,davis,ca, United States
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Authors
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