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Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques
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نویسنده
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nguyen s.m. ,antony k.m. ,dudley d.m. ,kohn s. ,simmons h.a. ,wolfe b. ,salamat m.s. ,teixeira l.b.c. ,wiepz g.j. ,thoong t.h. ,aliota m.t. ,weiler a.m. ,barry g.l. ,weisgrau k.l. ,vosler l.j. ,mohns m.s. ,breitbach m.e. ,stewart l.m. ,rasheed m.n. ,newman c.m. ,graham m.e. ,wieben o.e. ,turski p.a. ,johnson k.m. ,post j. ,hayes j.m. ,schultz-darken n. ,schotzko m.l. ,eudailey j.a. ,permar s.r. ,rakasz e.g. ,mohr e.l. ,capuano s. ,tarantal a.f. ,osorio j.e. ,o’connor s.l. ,friedrich t.c. ,o’connor d.h. ,golos t.g.
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منبع
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plos pathogens - 2017 - دوره : 13 - شماره : 5
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چکیده
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Infection with zika virus (zikv) is associated with human congenital fetal anomalies. to model fetal outcomes in nonhuman primates,we administered asian-lineage zikv subcutaneously to four pregnant rhesus macaques. while non-pregnant animals in a previous study contemporary with the current report clear viremia within 10–12 days,maternal viremia was prolonged in 3 of 4 pregnancies. fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus,both within normal range. zikv rna was detected in tissues from all four fetuses at term cesarean section. in all pregnancies,neutrophilic infiltration was present at the maternal-fetal interface (decidua,placenta,fetal membranes),in various fetal tissues,and in fetal retina,choroid,and optic nerve (first trimester infection only). consistent vertical transmission in this primate model may provide a platform to assess risk factors and test therapeutic interventions for interruption of fetal infection. the results may also suggest that maternal-fetal zikv transmission in human pregnancy may be more frequent than currently appreciated. © 2017 nguyen et al.
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آدرس
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department of obstetrics and gynecology,university of wisconsin-madison,madison,wi, United States, department of obstetrics and gynecology,university of wisconsin-madison,madison,wi, United States, department of pathology and laboratory medicine,university of wisconsin-madison,madison,wi, United States, department of radiology,university of wisconsin-madison,madison,wi, United States, wisconsin national primate research center,university of wisconsin-madison,madison,wi, United States, department of pathology and laboratory medicine,university of wisconsin-madison,madison,wi, United States, department of pathology and laboratory medicine,university of wisconsin-madison,madison,wi, United States, school of veterinary medicine,university of wisconsin-madison,madison,wi, United States, department of comparative biosciences,university of wisconsin-madison,madison,wi, United States, wisconsin national primate research center,university of wisconsin-madison,madison,wi, United States, department of pathobiological sciences,university of wisconsin-madison,madison,wi, United States, wisconsin national primate research center,university of wisconsin-madison,madison,wi, United States, wisconsin national primate research center,university of wisconsin-madison,madison,wi, United States, wisconsin national primate research center,university of wisconsin-madison,madison,wi, United States, wisconsin national primate research center,university of wisconsin-madison,madison,wi, United States, department of pathology and laboratory medicine,university of wisconsin-madison,madison,wi, United States, department of pathology and laboratory medicine,university of wisconsin-madison,madison,wi, United States, department of pathology and laboratory medicine,university of wisconsin-madison,madison,wi, United States, department of pathology and laboratory medicine,university of wisconsin-madison,madison,wi, United States, department of pathology and laboratory medicine,university of wisconsin-madison,madison,wi, United States, department of pathology and laboratory medicine,university of wisconsin-madison,madison,wi, United States, department of radiology,university of wisconsin-madison,madison,wi, United States, department of radiology,university of wisconsin-madison,madison,wi, United States, department of radiology,university of wisconsin-madison,madison,wi, United States, wisconsin national primate research center,university of wisconsin-madison,madison,wi, United States, wisconsin national primate research center,university of wisconsin-madison,madison,wi, United States, wisconsin national primate research center,university of wisconsin-madison,madison,wi, United States, wisconsin national primate research center,university of wisconsin-madison,madison,wi, United States, department of pediatrics and human vaccine institute,duke university medical center,durham,nc, United States, department of pediatrics and human vaccine institute,duke university medical center,durham,nc, United States, wisconsin national primate research center,university of wisconsin-madison,madison,wi, United States, department of pediatrics,university of wisconsin-madison,madison,wi, United States, iii,wisconsin national primate research center,university of wisconsin-madison,madison,wi, United States, departments of pediatrics and cell biology and human anatomy,university of california-davis,california national primate research center,davis,ca, United States, department of pathobiological sciences,university of wisconsin-madison,madison,wi, United States, department of pathology and laboratory medicine,university of wisconsin-madison,madison,wi, United States, wisconsin national primate research center,university of wisconsin-madison,madison,wi,united states,department of pathobiological sciences,university of wisconsin-madison,madison,wi, United States, department of pathology and laboratory medicine,university of wisconsin-madison,madison,wi,united states,wisconsin national primate research center,university of wisconsin-madison,madison,wi, United States, department of obstetrics and gynecology,university of wisconsin-madison,madison,wi,united states,wisconsin national primate research center,university of wisconsin-madison,madison,wi,united states,department of comparative biosciences,university of wisconsin-madison,madison,wi, United States
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Authors
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