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FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1
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نویسنده
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kim j.-h. ,park m.-e. ,nikapitiya c. ,kim t.-h. ,uddin m.b. ,lee h.-c. ,kim e. ,ma j.y. ,jung j.u. ,kim c.-j. ,lee j.-s.
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منبع
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plos pathogens - 2017 - دوره : 13 - شماره : 5
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چکیده
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Fas-associated factor-1 (faf1) is a component of the death-inducing signaling complex involved in fas-mediated apoptosis. it regulates nf-κb activity,ubiquitination,and proteasomal degradation. here,we found that faf1 positively regulates the type i interferon pathway. faf1gt/gtmice,which deficient in faf1,and faf1 knockdown immune cells were highly susceptible to rna virus infection and showed low levels of inflammatory cytokines and type i interferon (ifn) production. faf1 was bound competitively to nlrx1 and positively regulated type i ifn signaling by interfering with the interaction between nlrx1 and mavs,thereby freeing mavs to bind rig-i,which switched on the mavs-rig-i-mediated antiviral signaling cascade. these results highlight a critical role of faf1 in antiviral responses against rna virus infection. © 2017 kim et al.
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آدرس
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college of veterinary medicine,chungnam national university,daejeon, South Korea, college of veterinary medicine,chungnam national university,daejeon, South Korea, college of veterinary medicine,chungnam national university,daejeon, South Korea, college of veterinary medicine,chungnam national university,daejeon, South Korea, college of veterinary medicine,chungnam national university,daejeon,south korea,faculty of veterinary & animal science,sylhet agricultural university,sylhet, Bangladesh, college of veterinary medicine,chungnam national university,daejeon, South Korea, college of biological sciences and biotechnology,chungnam national university,daejeon, South Korea, korean medicine (km)-application center,korea institute of oriental medicine (kiom),daegu, South Korea, department of molecular microbiology and immunology,keck school of medicine,university of southern californiaca, United States, college of veterinary medicine,chungnam national university,daejeon, South Korea, college of veterinary medicine,chungnam national university,daejeon, South Korea
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Authors
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