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HIV-1 infection depletes human CD34+CD38-hematopoietic progenitor cells via pDC-dependent mechanisms
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نویسنده
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li g. ,zhao j. ,cheng l. ,jiang q. ,kan s. ,qin e. ,tu b. ,zhang x. ,zhang l. ,su l. ,zhang z.
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منبع
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plos pathogens - 2017 - دوره : 13 - شماره : 7
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چکیده
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Chronic human immunodeficiency virus-1 (hiv-1) infection in patients leads to multi-lineage hematopoietic abnormalities or pancytopenia. the deficiency in hematopoietic progenitor cells (hpcs) induced by hiv-1 infection has been proposed,but the relevant mechanisms are poorly understood. we report here that both human cd34+cd38-early and cd34+cd38+intermediate hpcs were maintained in the bone marrow (bm) of humanized mice. chronic hiv-1 infection preferentially depleted cd34+cd38-early hpcs in the bm and reduced their proliferation potential in vivo in both hiv-1-infected patients and humanized mice,while cd34+cd38+intermediate hscs were relatively unaffected. strikingly,depletion of plasmacytoid dendritic cells (pdcs) prevented human cd34+cd38-early hpcs from hiv-1 infection-induced depletion and functional impairment and restored the gene expression profile of purified cd34+hpcs in humanized mice. these findings suggest that pdcs contribute to the early hematopoietic suppression induced by chronic hiv-1 infection and provide a novel therapeutic target for the hematopoiesis suppression in hiv-1 patients. © 2017 li et al.
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آدرس
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the lineberger comprehensive cancer center,university of north carolina,chapel hill,nc, United States, research center for clinical & translational medicine,beijing 302 hospital,beijing, China, the lineberger comprehensive cancer center,university of north carolina,chapel hill,nc, United States, the lineberger comprehensive cancer center,university of north carolina,chapel hill,nc, United States, research center for clinical & translational medicine,beijing 302 hospital,beijing, China, treatment and research center for infectious diseases,beijing 302 hospital,beijing, China, treatment and research center for infectious diseases,beijing 302 hospital,beijing, China, treatment and research center for infectious diseases,beijing 302 hospital,beijing, China, key laboratory of infection and immunity,institute of biophysics,chinese academy of science,beijing, China, the lineberger comprehensive cancer center,university of north carolina,chapel hill,nc,united states,key laboratory of infection and immunity,institute of biophysics,chinese academy of science,beijing, China, the lineberger comprehensive cancer center,university of north carolina,chapel hill,nc,united states,research center for clinical & translational medicine,beijing 302 hospital,beijing, China
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Authors
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