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Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development
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نویسنده
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kumar r. ,herold j.l. ,schady d. ,davis j. ,kopetz s. ,martinez-moczygemba m. ,murray b.e. ,han f. ,li y. ,callaway e. ,chapkin r.s. ,dashwood w.-m. ,dashwood r.h. ,berry t. ,mackenzie c. ,xu y.
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منبع
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plos pathogens - 2017 - دوره : 13 - شماره : 7
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چکیده
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Streptococcus gallolyticus subsp. gallolyticus (sg) has long been known to have a strong association with colorectal cancer (crc). this knowledge has important clinical implications,and yet little is known about the role of sg in the development of crc. here we demonstrate that sg promotes human colon cancer cell proliferation in a manner that depends on cell context,bacterial growth phase and direct contact between bacteria and colon cancer cells. in addition,we observed increased level of β-catenin,c-myc and pcna in colon cancer cells following incubation with sg. knockdown or inhibition of β-catenin abolished the effect of sg. furthermore,mice administered with sg had significantly more tumors,higher tumor burden and dysplasia grade,and increased cell proliferation and β-catenin staining in colonic crypts compared to mice receiving control bacteria. finally,we showed that sg is present in the majority of crc patients and is preferentially associated with tumor compared to normal tissues obtained from crc patients. these results taken together establish for the first time a tumor-promoting role of sg that involves specific bacterial and host factors and have important clinical implications. © 2017 kumar et al.
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آدرس
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center for infectious and inflammatory diseases,institute of biosciences and technology,texas a&m health science center,houston,tx, United States, center for infectious and inflammatory diseases,institute of biosciences and technology,texas a&m health science center,houston,tx, United States, department of pathology,baylor college of medicine,houston,tx, United States, department of gastrointestinal medical oncology,the university of texas m. d. anderson cancer center,houston,tx,united states,epidemiology,the university of texas m. d. anderson cancer center,houston,tx, United States, department of gastrointestinal medical oncology,the university of texas m. d. anderson cancer center,houston,tx, United States, center for infectious and inflammatory diseases,institute of biosciences and technology,texas a&m health science center,houston,tx, United States, department of internal medicine,university of texas health science center,houston,tx,united states,department of microbiology and microbial genetics,university of texas health science center,houston,tx, United States, harbin institute of technology,harbin, China, harbin institute of technology,harbin, China, program in integrative nutrition and complex diseases,texas a&m university,college station,tx, United States, program in integrative nutrition and complex diseases,texas a&m university,college station,tx, United States, center for epigenetics and disease prevention,institute of biosciences and technology,texas a&m health science center,houston,tx, United States, center for epigenetics and disease prevention,institute of biosciences and technology,texas a&m health science center,houston,tx, United States, center for translational cancer research,institute of biosciences and technology,texas a&m health science center,houston,tx, United States, department of microbiology and microbial genetics,university of texas health science center,houston,tx, United States, center for infectious and inflammatory diseases,institute of biosciences and technology,texas a&m health science center,houston,tx,united states,department of microbiology and microbial genetics,university of texas health science center,houston,tx,united states,department of microbial pathogenesis and immunology,college of medicine,texas a&m health science center,college station,tx, United States
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Authors
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