plos pathogens سال:2017 - دوره:13

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plos pathogens
سال:2017 - دوره:13 - شماره:9

A highly conserved amino acid in VP1 regulates maturation of enterovirus 71 A novel mechanism of antibody-mediated enhancement of flavivirus infection A single gp120 residue can affect HIV-1 tropism in macaques An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport Bacterial toxins: Offensive,defensive,or something else altogether? Binding of a C-type lectin’s coiled-coil domain to the Domeless receptor directly activates the JAK/STAT pathway in the shrimp immune response to bacterial infection Cancer therapy in a microbial bottle: Uncorking the novel biology of the protozoan Toxoplasma gondii Cell cycle stage-specific transcriptional activation of cyclins mediated by HAT2-dependant H4K10 acetylation of promoters in Leishmania donovani Comment on Rohrscheib et al. 2016 Intensity of mutualism breakdown is determined by temperature not amplification of Wolbachia genes Consequences of insecticide resistance on malaria transmission Convergent evolution involving dimeric and trimeric dUTPases in pathogenicity island mobilization Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites Different rates of spontaneous mutation of chloroplastic and nuclear viroids as determined by high-fidelity ultra-deep sequencing Diminished neutrophil extracellular trap (NET) formation is a novel innate immune deficiency induced by acute ethanol exposure in polymicrobial sepsis,which can be rescued by CXCL1 Divergent LysM effectors contribute to the virulence of Beauveria bassiana by evasion of insect immune defenses Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection From bacterial killing to immune modulation: Recent insights into the functions of lysozyme Genetic and epigenetic engines of diversity in pathogenic microbes HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways HCV-induced autophagosomes are generated via homotypic fusion of phagophores that mediate HCV RNA replication HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis Hypoxia-inducible factor-1 alpha as a therapeutic target for primary effusion lymphoma IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell kick and kill in strategy for virus eradication In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication Inhibition of melanization by serpin-5 and serpin-9 promotes baculovirus infection in cotton bollworm Helicoverpa armigera Innate activation of human primary epithelial cells broadens the host response to Mycobacterium tuberculosis in the airways Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer Malaria-induced interferon-γ drives the expansion of Tbethiatypical memory B cells Male hormones activate EphA2 to facilitate Kaposi’s sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi’s sarcoma Novel cutting-edge metabolite-based diagnostic tools for aspergillosis PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation Plasmodium heme biosynthesis: To be or not to be essential? Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells Response to: Comment on Rohrscheib et al. 2016 Intensity of mutualism breakdown is determined by temperature not amplification of Wolbachia genes Reversible unfolding of infectious prion assemblies reveals the existence of an oligomeric elementary brick Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates Staphylococcal enterotoxin-like X (SElX) is a unique superantigen with functional features of two major families of staphylococcal virulence factors Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response The Kaposi's sarcoma-associated herpesvirus (KSHV) non-structural membrane protein K15 is required for viral lytic replication and may represent a therapeutic target The Staphylococcus aureus superantigen SElX is a bifunctional toxin that inhibits neutrophil function The microbiome and the hallmarks of cancer The risk of sustained sexual transmission of Zika is underestimated The transcription factor CHOP,an effector of the integrated stress response,is required for host sensitivity to the fungal intracellular pathogen Histoplasma capsulatum Vpma phase variation is important for survival and persistence of Mycoplasma agalactiae in the immunocompetent host Zika genomics urgently need standardized and curated reference sequences mT-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy