Emerging Functions for the Staphylococcus aureus RNome

Staphylococcus aureus is a leading pathogen for animals and humans,not only being one of the most frequently isolated bacteria in hospital-associated infections but also causing diseases in the community. to coordinate the expression of its numerous virulence genes for growth and survival,s. aureus uses various signalling pathways that include two-component regulatory systems,transcription factors,and also around 250 regulatory rnas. biological roles have only been determined for a handful of these srnas,including cis,trans,and cis-trans acting rnas,some internally encoding small,functional peptides and others possessing dual or multiple functions. here we put forward an inventory of these fascinating srnas; the proteins involved in their activities; and those involved in stress response,metabolisms,and virulence. © 2013 guillet et al.