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The Battle between Rotavirus and Its Host for Control of the Interferon Signaling Pathway
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نویسنده
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arnold m.m. ,sen a. ,greenberg h.b. ,patton j.t.
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منبع
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plos pathogens - 2013 - دوره : 9 - شماره : 1
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چکیده
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Viral pathogens must overcome innate antiviral responses to replicate successfully in the host organism. some of the mechanisms viruses use to interfere with antiviral responses in the infected cell include preventing detection of viral components,perturbing the function of transcription factors that initiate antiviral responses,and inhibiting downstream signal transduction. rna viruses with small genomes and limited coding space often express multifunctional proteins that modulate several aspects of the normal host response to infection. one such virus,rotavirus,is an important pediatric pathogen that causes severe gastroenteritis,leading to ~450,000 deaths globally each year. in this review,we discuss the nature of the innate antiviral responses triggered by rotavirus infection and the viral mechanisms for inhibiting these responses.
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آدرس
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laboratory of infectious diseases,national institute of allergy and infectious diseases,national institutes of health,bethesda,md,united states,department of microbiology and immunology,louisiana state university health sciences center - shreveport,shreveport,la, United States, department of medicine and microbiology and immunology,stanford university,stanford,ca,united states,va palo alto health care system,palo alto,ca, United States, department of medicine and microbiology and immunology,stanford university,stanford,ca,united states,va palo alto health care system,palo alto,ca, United States, laboratory of infectious diseases,national institute of allergy and infectious diseases,national institutes of health,bethesda,md, United States
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Authors
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