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Bifurcation of Arabidopsis NLR Immune Signaling via Ca2+-Dependent Protein Kinases
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نویسنده
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gao x. ,chen x. ,lin w. ,chen s. ,lu d. ,niu y. ,li l. ,cheng c. ,mccormack m. ,sheen j. ,shan l. ,he p.
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منبع
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plos pathogens - 2013 - دوره : 9 - شماره : 1
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چکیده
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Nucleotide-binding domain leucine-rich repeat (nlr) protein complexes sense infections and trigger robust immune responses in plants and humans. activation of plant nlr resistance (r) proteins by pathogen effectors launches convergent immune responses,including programmed cell death (pcd),reactive oxygen species (ros) production and transcriptional reprogramming with elusive mechanisms. functional genomic and biochemical genetic screens identified six closely related arabidopsis ca2+-dependent protein kinases (cpks) in mediating bifurcate immune responses activated by nlr proteins,rps2 and rpm1. the dynamics of differential cpk1/2 activation by pathogen effectors controls the onset of cell death. sustained cpk4/5/6/11 activation directly phosphorylates a specific subgroup of wrky transcription factors,wrky8/28/48,to synergistically regulate transcriptional reprogramming crucial for nlr-dependent restriction of pathogen growth,whereas cpk1/2/4/11 phosphorylate plasma membrane-resident nadph oxidases for ros production. our studies delineate bifurcation of complex signaling mechanisms downstream of nlr immune sensors mediated by the myriad action of cpks with distinct substrate specificity and subcellular dynamics. © 2013 gao et al.
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آدرس
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department of biochemistry and biophysics,institute for plant genomics and biotechnology,texas aandm university,college station,tx,united states,department of plant pathology and microbiology,institute for plant genomics and biotechnology,texas aandm university,college station,tx, United States, department of plant pathology and microbiology,institute for plant genomics and biotechnology,texas aandm university,college station,tx, United States, department of plant pathology and microbiology,institute for plant genomics and biotechnology,texas aandm university,college station,tx, United States, department of biology,genetics institute,plant molecular and cellular biology program,interdisciplinary center for biotechnology research,university of florida,gainesville,fl, United States, department of biochemistry and biophysics,institute for plant genomics and biotechnology,texas aandm university,college station,tx, United States, department of genetics,harvard medical school,department of molecular biology and center for computational and integrative biology,massachusetts general hospital,boston,ma, United States, department of genetics,harvard medical school,department of molecular biology and center for computational and integrative biology,massachusetts general hospital,boston,ma, United States, department of biochemistry and biophysics,institute for plant genomics and biotechnology,texas aandm university,college station,tx, United States, department of genetics,harvard medical school,department of molecular biology and center for computational and integrative biology,massachusetts general hospital,boston,ma, United States, department of genetics,harvard medical school,department of molecular biology and center for computational and integrative biology,massachusetts general hospital,boston,ma, United States, department of plant pathology and microbiology,institute for plant genomics and biotechnology,texas aandm university,college station,tx, United States, department of biochemistry and biophysics,institute for plant genomics and biotechnology,texas aandm university,college station,tx, United States
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Authors
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