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Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells
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نویسنده
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hollenbaugh j.a. ,gee p. ,baker j. ,daly m.b. ,amie s.m. ,tate j. ,kasai n. ,kanemura y. ,kim d.-h. ,ward b.m. ,koyanagi y. ,kim b.
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منبع
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plos pathogens - 2013 - دوره : 9 - شماره : 6
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چکیده
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Samhd1 is a newly identified anti-hiv host factor that has a dntp triphosphohydrolase activity and depletes intracellular dntp pools in non-dividing myeloid cells. since dna viruses utilize cellular dntps,we investigated whether samhd1 limits the replication of dna viruses in non-dividing myeloid target cells. indeed,two double stranded dna viruses,vaccinia and herpes simplex virus type 1,are subject to samhd1 restriction in non-dividing target cells in a dntp dependent manner. using a thymidine kinase deficient strain of vaccinia virus,we demonstrate a greater restriction of viral replication in non-dividing cells expressing samhd1. therefore,this study suggests that samhd1 is a potential innate anti-viral player that suppresses the replication of a wide range of dna viruses,as well as retroviruses,which infect non-dividing myeloid cells. © 2013 hollenbaugh et al.
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آدرس
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department of microbiology and immunology,university of rochester,rochester,ny,united states,center for drug discovery,the department of pediatrics,emory university,atlanta,ga, United States, laboratory of viral pathogenesis,institute for virus research,kyoto university,kyoto, Japan, department of microbiology and immunology,university of rochester,rochester,ny, United States, department of microbiology and immunology,university of rochester,rochester,ny,united states,center for drug discovery,the department of pediatrics,emory university,atlanta,ga, United States, department of microbiology and immunology,university of rochester,rochester,ny, United States, department of microbiology and immunology,university of rochester,rochester,ny, United States, laboratory of viral pathogenesis,institute for virus research,kyoto university,kyoto, Japan, laboratory of viral pathogenesis,institute for virus research,kyoto university,kyoto, Japan, department of pharmacy,kyung-hee university,seoul, South Korea, department of microbiology and immunology,university of rochester,rochester,ny, United States, laboratory of viral pathogenesis,institute for virus research,kyoto university,kyoto, Japan, department of microbiology and immunology,university of rochester,rochester,ny,united states,center for drug discovery,the department of pediatrics,emory university,atlanta,ga,united states,department of pharmacy,kyung-hee university,seoul, South Korea
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Authors
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