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Nuclear Hormone Receptor Regulation of MicroRNAs Controls Innate Immune Responses in C. elegans
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نویسنده
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liu f. ,he c.-x. ,luo l.-j. ,zou q.-l. ,zhao y.-x. ,saini r. ,han s.-f. ,knölker h.-j. ,wang l.-s. ,ge b.-x.
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منبع
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plos pathogens - 2013 - دوره : 9 - شماره : 8
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چکیده
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Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. signaling in the conserved p38/pmk-1 map kinase pathway regulates innate immunity. in this study,we show that the caenorhabditis elegans nuclear receptor daf-12 negatively regulates the defense against pathogens via the downstream let-7 family of micrornas,which directly target skn-1,a gene downstream of pmk-1. these findings identify nuclear hormone receptors as components of innate immunity that crosstalk with the p38/pmk-1 map kinase pathway. © 2013 liu et al.
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آدرس
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institute of health sciences,shanghai institutes for biological sciences,chinese academy of sciences/shanghai jiaotong university school of medicine,shanghai,china,graduate school of chinese academy of sciences,beijing, China, shanghai key laboratory of tuberculosis,clinical and translational research center,shanghai pulmonary hospital,tongji university school of medicine,shanghai, China, institute of health sciences,shanghai institutes for biological sciences,chinese academy of sciences/shanghai jiaotong university school of medicine,shanghai, China, institute of health sciences,shanghai institutes for biological sciences,chinese academy of sciences/shanghai jiaotong university school of medicine,shanghai, China, institute of health sciences,shanghai institutes for biological sciences,chinese academy of sciences/shanghai jiaotong university school of medicine,shanghai, China, department of chemistry,technical university of dresden,dresden, Germany, key laboratory of cell differentiation and apoptosis of chinese ministry of education,shanghai jiao-tong university school of medicine,shanghai, China, department of chemistry,technical university of dresden,dresden, Germany, key laboratory of cell differentiation and apoptosis of chinese ministry of education,shanghai jiao-tong university school of medicine,shanghai, China, institute of health sciences,shanghai institutes for biological sciences,chinese academy of sciences/shanghai jiaotong university school of medicine,shanghai,china,shanghai key laboratory of tuberculosis,clinical and translational research center,shanghai pulmonary hospital,tongji university school of medicine,shanghai, China
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Authors
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