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Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion
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نویسنده
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tomavo s. ,slomianny c. ,meissner m. ,carruthers v.b.
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منبع
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plos pathogens - 2013 - دوره : 9 - شماره : 10
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چکیده
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Toxoplasma (toxoplasmosis) and plasmodium (malaria) use unique secretory organelles for migration,cell invasion,manipulation of host cell functions,and cell egress. in particular,the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection. new findings reveal that the contents of these organelles,which are transported through the endoplasmic reticulum (er) and golgi,also require the parasite endosome-like system to access their respective organelles. in this review,we discuss recent findings that demonstrate that these parasites reduced their endosomal system and modified classical regulators of this pathway for the biogenesis of apical organelles. © 2013 tomavo et al.
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آدرس
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center for infection and immunity of lille,cnrs umr 8204,inserm u 1019,institut pasteur de lille,université lille nord de france,lille, France, laboratory of cell physiology,inserm u 1003,université lille nord de france,villeneuve d'ascq,lille, France, wellcome trust centre for molecular parasitology,institute of infection,immunity and inflammation,university of glasgow,glasgow, United Kingdom, department of microbiology and immunology,university of michigan medical school,ann arbor,mi, United States
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Authors
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