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New World Bats Harbor Diverse Influenza A Viruses
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نویسنده
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tong s. ,zhu x. ,li y. ,shi m. ,zhang j. ,bourgeois m. ,yang h. ,chen x. ,recuenco s. ,gomez j. ,chen l.-m. ,johnson a. ,tao y. ,dreyfus c. ,yu w. ,mcbride r. ,carney p.j. ,gilbert a.t. ,chang j. ,guo z. ,davis c.t. ,paulson j.c. ,stevens j. ,rupprecht c.e. ,holmes e.c. ,wilson i.a. ,donis r.o.
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منبع
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plos pathogens - 2013 - دوره : 9 - شماره : 10
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چکیده
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Aquatic birds harbor diverse influenza a viruses and are a major viral reservoir in nature. the recent discovery of influenza viruses of a new h17n10 subtype in central american fruit bats suggests that other new world species may similarly carry divergent influenza viruses. using consensus degenerate rt-pcr,we identified a novel influenza a virus,designated as h18n11,in a flat-faced fruit bat (artibeus planirostris) from peru. serologic studies with the recombinant h18 protein indicated that several peruvian bat species were infected by this virus. phylogenetic analyses demonstrate that,in some gene segments,new world bats harbor more influenza virus genetic diversity than all other mammalian and avian species combined,indicative of a long-standing host-virus association. structural and functional analyses of the hemagglutinin and neuraminidase indicate that sialic acid is not a ligand for virus attachment nor a substrate for release,suggesting a unique mode of influenza a virus attachment and activation of membrane fusion for entry into host cells. taken together,these findings indicate that bats constitute a potentially important and likely ancient reservoir for a diverse pool of influenza viruses.
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آدرس
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division of viral diseases,centers for disease control and prevention,atlanta,ga, United States, department of integrative structural and computational biology,the scripps research institute,la jolla,ca, United States, division of viral diseases,centers for disease control and prevention,atlanta,ga, United States, sydney emerging infections and biosecurity institute,school of biological sciences and sydney medical school,the university of sydney,sydney,nsw, Australia, division of viral diseases,centers for disease control and prevention,atlanta,ga, United States, influenza division,centers for disease control and prevention,atlanta,ga, United States, influenza division,centers for disease control and prevention,atlanta,ga, United States, division of viral diseases,centers for disease control and prevention,atlanta,ga, United States, division of high consequence pathogens and pathology,centers for disease control and prevention,atlanta,ga, United States, direccion general de epidemiologia,ministerio de salud - minsa,lima, Peru, influenza division,centers for disease control and prevention,atlanta,ga, United States, influenza division,centers for disease control and prevention,atlanta,ga, United States, division of viral diseases,centers for disease control and prevention,atlanta,ga, United States, department of integrative structural and computational biology,the scripps research institute,la jolla,ca, United States, department of integrative structural and computational biology,the scripps research institute,la jolla,ca, United States, department of chemical physiology,the scripps research institute,la jolla,ca, United States, influenza division,centers for disease control and prevention,atlanta,ga, United States, division of high consequence pathogens and pathology,centers for disease control and prevention,atlanta,ga, United States, influenza division,centers for disease control and prevention,atlanta,ga, United States, influenza division,centers for disease control and prevention,atlanta,ga, United States, influenza division,centers for disease control and prevention,atlanta,ga, United States, department of integrative structural and computational biology,the scripps research institute,la jolla,ca,united states,department of chemical physiology,the scripps research institute,la jolla,ca, United States, influenza division,centers for disease control and prevention,atlanta,ga, United States, division of high consequence pathogens and pathology,centers for disease control and prevention,atlanta,ga,united states,global alliance for rabies control,the scripps research institute,la jolla,ca, United States, sydney emerging infections and biosecurity institute,school of biological sciences and sydney medical school,the university of sydney,sydney,nsw,australia,fogarty international center,national institutes of health,bethesda,md, United States, department of integrative structural and computational biology,the scripps research institute,la jolla,ca,united states,skaggs institute for chemical biology,the scripps research institute,la jolla,ca, United States, influenza division,centers for disease control and prevention,atlanta,ga, United States
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Authors
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