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Prospective Antiretroviral Treatment of Asymptomatic,HIV-1 Infected Controllers
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نویسنده
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hatano h. ,yukl s.a. ,ferre a.l. ,graf e.h. ,somsouk m. ,sinclair e. ,abdel-mohsen m. ,liegler t. ,harvill k. ,hoh r. ,palmer s. ,bacchetti p. ,hunt p.w. ,martin j.n. ,mccune j.m. ,tracy r.p. ,busch m.p. ,o'doherty u. ,shacklett b.l. ,wong j.k. ,deeks s.g.
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منبع
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plos pathogens - 2013 - دوره : 9 - شماره : 10
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چکیده
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The study of hiv-infected controllers who are able to maintain low levels of plasma hiv rna in the absence of antiretroviral therapy (art) may provide insights for hiv cure and vaccine strategies. despite maintaining very low levels of plasma viremia,controllers have elevated immune activation and accelerated atherosclerosis. however,the degree to which low-level replication contributes to these phenomena is not known. sixteen asymptomatic controllers were prospectively treated with art for 24 weeks. controllers had a statistically significant decrease in ultrasensitive plasma and rectal hiv rna levels with art. markers of t cell activation/dysfunction in blood and gut mucosa also decreased substantially with art. similar reductions were observed in the subset of elite controllers with pre-art plasma hiv rna levels below conventional assays (<40 copies/ml). these data confirm that hiv replication persists in controllers and contributes to a chronic inflammatory state. art should be considered for these individuals (clinicaltrials.gov nct01025427).
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آدرس
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department of medicine,university of california san francisco,san francisco,ca, United States, department of medicine,university of california san francisco,san francisco,ca,united states,department of medicine,san francisco veterans affairs medical center,san francisco,ca, United States, department of medical microbiology and immunology,school of medicine,university of california,davis,davis,ca, United States, department of pathology and laboratory medicine,university of pennsylvania,philadelphia,pa, United States, department of medicine,university of california san francisco,san francisco,ca, United States, department of medicine,university of california san francisco,san francisco,ca, United States, department of medicine,university of california san francisco,san francisco,ca, United States, department of medicine,university of california san francisco,san francisco,ca, United States, department of medicine,university of california san francisco,san francisco,ca, United States, department of medicine,university of california san francisco,san francisco,ca, United States, karolinska institutet and swedish institute for infectious disease control,solna,sweden,centre for virus research,westmead millennium institute and university of sydney,westmead, Australia, department of epidemiology and biostatistics,university of california san francisco,san francisco,ca, United States, department of medicine,university of california san francisco,san francisco,ca, United States, department of epidemiology and biostatistics,university of california san francisco,san francisco,ca, United States, department of medicine,university of california san francisco,san francisco,ca, United States, departments of pathology and biochemistry,university of vermont,colchester,vt, United States, blood systems research institute,san francisco,ca,united states,department of laboratory medicine,university of california san francisco,san francisco,ca, United States, department of pathology and laboratory medicine,university of pennsylvania,philadelphia,pa, United States, department of medical microbiology and immunology,school of medicine,university of california,davis,davis,ca, United States, department of medicine,university of california san francisco,san francisco,ca,united states,department of medicine,san francisco veterans affairs medical center,san francisco,ca, United States, department of medicine,university of california san francisco,san francisco,ca, United States
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Authors
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