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TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis
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نویسنده
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park y.-j. ,yoon s.-j. ,suh h.-w. ,kim d.o. ,park j.-r. ,jung h. ,kim t.-d. ,yoon s.r. ,min j.-k. ,na h.-j. ,lee s.-j. ,lee h.g. ,lee y.h. ,lee h.-b. ,choi i.
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منبع
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plos pathogens - 2013 - دوره : 9 - شماره : 10
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چکیده
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Thioredoxin-interacting protein (txnip) has multiple functions,including tumor suppression and involvement in cell proliferation and apoptosis. however,its role in the inflammatory process remains unclear. in this report,we demonstrate that txnip-/- mice are significantly more susceptible to lipopolysaccharide (lps)-induced endotoxic shock. in response to lps,txnip-/- macrophages produced significantly higher levels of nitric oxide (no) and inducible nitric oxide synthase (inos),and an inos inhibitor rescued txnip-/- mice from endotoxic shock-induced death,demonstrating that no is a major factor in txnip-mediated endotoxic shock. this susceptibility phenotype of txnip-/- mice occurred despite reduced il-1β secretion due to increased s-nitrosylation of nlrp3 compared to wild-type controls. taken together,these data demonstrate that txnip is a novel molecule that links no synthesis and nlrp3 inflammasome activation during endotoxic shock. © 2013 park et al.
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آدرس
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immunotherapy research center,korea research institute of bioscience and biotechnology,yuseong-gu,daejeon,south korea,department of functional genomics,university of science and technology,yuseong-gu,daejeon, South Korea, immunotherapy research center,korea research institute of bioscience and biotechnology,yuseong-gu,daejeon,south korea,department of functional genomics,university of science and technology,yuseong-gu,daejeon, South Korea, immunotherapy research center,korea research institute of bioscience and biotechnology,yuseong-gu,daejeon, South Korea, immunotherapy research center,korea research institute of bioscience and biotechnology,yuseong-gu,daejeon,south korea,department of functional genomics,university of science and technology,yuseong-gu,daejeon, South Korea, immunotherapy research center,korea research institute of bioscience and biotechnology,yuseong-gu,daejeon, South Korea, immunotherapy research center,korea research institute of bioscience and biotechnology,yuseong-gu,daejeon,south korea,department of functional genomics,university of science and technology,yuseong-gu,daejeon, South Korea, immunotherapy research center,korea research institute of bioscience and biotechnology,yuseong-gu,daejeon,south korea,department of functional genomics,university of science and technology,yuseong-gu,daejeon, South Korea, immunotherapy research center,korea research institute of bioscience and biotechnology,yuseong-gu,daejeon,south korea,department of functional genomics,university of science and technology,yuseong-gu,daejeon, South Korea, immunotherapy research center,korea research institute of bioscience and biotechnology,yuseong-gu,daejeon,south korea,department of biomolecular science,university of science and technology,yuseong-gu,daejeon, South Korea, regenerative medicine research center,korea research institute of bioscience and biotechnology,yuseong-gu,daejeon, South Korea, medical genomics research center,korea research institute of bioscience and biotechnology,yuseong-gu,daejeon, South Korea, medical genomics research center,korea research institute of bioscience and biotechnology,yuseong-gu,daejeon, South Korea, department of anatomy,school of medicine,chungnam national university,chung-gu,daejeon, South Korea, department of biochemistry,college of natural sciences,kangwon national university,chuncheon, South Korea, immunotherapy research center,korea research institute of bioscience and biotechnology,yuseong-gu,daejeon,south korea,department of functional genomics,university of science and technology,yuseong-gu,daejeon, South Korea
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Authors
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