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Chronic Exposure to Type-I IFN under Lymphopenic Conditions Alters CD4 T Cell Homeostasis
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نویسنده
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le saout c. ,hasley r.b. ,imamichi h. ,tcheung l. ,hu z. ,luckey m.a. ,park j.-h. ,durum s.k. ,smith m. ,rupert a.w. ,sneller m.c. ,lane h.c. ,catalfamo m.
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منبع
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plos pathogens - 2014 - دوره : 10 - شماره : 3
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چکیده
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Hiv infection and the associated chronic immune activation alter t cell homeostasis leading to cd4 t cell depletion and cd8 t cell expansion. the mechanisms behind these outcomes are not totally defined and only partially explained by the direct cytopathic effect of the virus. in this manuscript,we addressed the impact of lymphopenia and chronic exposure to ifn-α on t cell homeostasis. in a lymphopenic murine model,this interaction led to decreased cd4 counts and cd8 t cell expansion in association with an increase in the signal transducer and activator of transcription 1 (stat1) levels resulting in enhanced cd4 t cell responsiveness to ifn-α. thus,in the setting of hiv infection,chronic stimulation of this pathway could be detrimental for cd4 t cell homeostasis.
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آدرس
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cmrs/laboratory of immunoregulation,niaid,nih,bethesda,md, United States, cmrs/laboratory of immunoregulation,niaid,nih,bethesda,md, United States, cmrs/laboratory of immunoregulation,niaid,nih,bethesda,md, United States, cmrs/laboratory of immunoregulation,niaid,nih,bethesda,md, United States, biostatistics research branch,dcr,niaid,nih,bethesda,md, United States, experimental immunology branch,ccr,nci,nih,bethesda,md, United States, experimental immunology branch,ccr,nci,nih,bethesda,md, United States, laboratory of immunoregulation,ccr,nci,nih,frederick,md, United States, cmrs/laboratory of immunoregulation,niaid,nih,bethesda,md, United States, aids monitoring labs. leidos biomedical research,inc,frederick,md, United States, cmrs/laboratory of immunoregulation,niaid,nih,bethesda,md, United States, cmrs/laboratory of immunoregulation,niaid,nih,bethesda,md, United States, cmrs/laboratory of immunoregulation,niaid,nih,bethesda,md, United States
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Authors
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