|
|
|
|
Fructose-Asparagine Is a Primary Nutrient during Growth of Salmonella in the Inflamed Intestine
|
|
|
|
|
|
|
|
نویسنده
|
ali m.m. ,newsom d.l. ,gonzález j.f. ,sabag-daigle a. ,stahl c. ,steidley b. ,dubena j. ,dyszel j.l. ,smith j.n. ,dieye y. ,arsenescu r. ,boyaka p.n. ,krakowka s. ,romeo t. ,behrman e.j. ,white p. ,ahmer b.m.m.
|
|
منبع
|
plos pathogens - 2014 - دوره : 10 - شماره : 6
|
|
چکیده
|
Salmonella enterica serovar typhimurium (salmonella) is one of the most significant food-borne pathogens affecting both humans and agriculture. we have determined that salmonella encodes an uptake and utilization pathway specific for a novel nutrient,fructose-asparagine (f-asn),which is essential for salmonella fitness in the inflamed intestine (modeled using germ-free,streptomycin-treated,ex-germ-free with human microbiota,and il10-/- mice). the locus encoding f-asn utilization,fra,provides an advantage only if salmonella can initiate inflammation and use tetrathionate as a terminal electron acceptor for anaerobic respiration (the fra phenotype is lost in salmonella spi1- spi2- or ttra mutants,respectively). the severe fitness defect of a salmonella fra mutant suggests that f-asn is the primary nutrient utilized by salmonella in the inflamed intestine and that this system provides a valuable target for novel therapies. © 2014 ali et al.
|
|
|
|
|
آدرس
|
department of microbiology,the ohio state university,columbus,oh,united states,department of medical microbiology and immunology,mansoura university,mansoura, Egypt, center for microbial pathogenesis,the research institute at nationwide children's hospital,columbus,oh, United States, department of microbial infection and immunity,the ohio state university,columbus,oh, United States, department of microbial infection and immunity,the ohio state university,columbus,oh, United States, department of microbiology,the ohio state university,columbus,oh, United States, department of microbial infection and immunity,the ohio state university,columbus,oh, United States, department of veterinary biosciences,the ohio state university,columbus,oh, United States, department of microbiology,the ohio state university,columbus,oh, United States, department of microbiology,the ohio state university,columbus,oh, United States, department of microbiology,the ohio state university,columbus,oh, United States, department of internal medicine,the ohio state university,columbus,oh, United States, department of veterinary biosciences,the ohio state university,columbus,oh, United States, department of veterinary biosciences,the ohio state university,columbus,oh, United States, department of microbiology and cell science,university of florida,gainesville,fl, United States, department of chemistry and biochemistry,the ohio state university,columbus,oh, United States, center for microbial pathogenesis,the research institute at nationwide children's hospital,columbus,oh, United States, department of microbiology,the ohio state university,columbus,oh,united states,department of microbial infection and immunity,the ohio state university,columbus,oh, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|