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HIV-1 Capture and Transmission by Dendritic Cells: the Role of Viral Glycolipids and the Cellular Receptor Siglec-1
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نویسنده
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izquierdo-useros n. ,lorizate m. ,mclaren p.j. ,telenti a. ,kräusslich h.-g. ,martinez-picado j.
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منبع
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plos pathogens - 2014 - دوره : 10 - شماره : 7
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چکیده
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Dendritic cells (dcs) are essential in order to combat invading viruses and trigger antiviral responses. paradoxically,in the case of hiv-1,dcs might contribute to viral pathogenesis through trans-infection,a mechanism that promotes viral capture and transmission to target cells,especially after dc maturation. in this review,we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin siglec-1 as critical determinants for hiv-1 capture and storage by mature dcs and for dc-mediated trans-infection of t cells. in contrast,dc-sign,long considered to be the main receptor for dc capture of hiv-1,plays a minor role in mature dc-mediated hiv-1 capture and trans-infection. © 2014 izquierdo-useros et al.
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آدرس
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aids research institute irsicaixa,institut d'investigació en ciències de la salut germans trias i pujol,universitat autònoma de barcelona,badalona, Spain, unidad de biofisica (csic-upv/ehu) and departamento de bioquímica,universidad del pais vasco,bilbao, Spain, institute of microbiology,university hospital center and university of lausanne,lausanne, Switzerland, institute of microbiology,university hospital center and university of lausanne,lausanne, Switzerland, department of infectious diseases,virology,universitätsklinikum heidelberg,heidelberg, Germany, aids research institute irsicaixa,institut d'investigació en ciències de la salut germans trias i pujol,universitat autònoma de barcelona,badalona,spain,universitat de vic-universitat central de catalunya (uvic-ucc),vic,spain,institució catalana de recerca i estudis avançats (icrea),barcelona, Spain
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Authors
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