|
|
|
|
Israeli Acute Paralysis Virus: Epidemiology,Pathogenesis and Implications for Honey Bee Health
|
|
|
|
|
|
|
|
نویسنده
|
chen y.p. ,pettis j.s. ,corona m. ,chen w.p. ,li c.j. ,spivak m. ,visscher p.k. ,degrandi-hoffman g. ,boncristiani h. ,zhao y. ,vanengelsdorp d. ,delaplane k. ,solter l. ,drummond f. ,kramer m. ,lipkin w.i. ,palacios g. ,hamilton m.c. ,smith b. ,huang s.k. ,zheng h.q. ,li j.l. ,zhang x. ,zhou a.f. ,wu l.y. ,zhou j.z. ,lee m.-l. ,teixeira e.w. ,li z.g. ,evans j.d.
|
|
منبع
|
plos pathogens - 2014 - دوره : 10 - شماره : 7
|
|
چکیده
|
Israeli acute paralysis virus (iapv) is a widespread rna virus of honey bees that has been linked with colony losses. here we describe the transmission,prevalence,and genetic traits of this virus,along with host transcriptional responses to infections. further,we present rnai-based strategies for limiting an important mechanism used by iapv to subvert host defenses. our study shows that iapv is established as a persistent infection in honey bee populations,likely enabled by both horizontal and vertical transmission pathways. the phenotypic differences in pathology among different strains of iapv found globally may be due to high levels of standing genetic variation. microarray profiles of host responses to iapv infection revealed that mitochondrial function is the most significantly affected biological process,suggesting that viral infection causes significant disturbance in energy-related host processes. the expression of genes involved in immune pathways in adult bees indicates that iapv infection triggers active immune responses. the evidence that silencing an iapv-encoded putative suppressor of rnai reduces iapv replication suggests a functional assignment for a particular genomic region of iapv and closely related viruses from the family dicistroviridae,and indicates a novel therapeutic strategy for limiting multiple honey bee viruses simultaneously and reducing colony losses due to viral diseases. we believe that the knowledge and insights gained from this study will provide a new platform for continuing studies of the iapv-host interactions and have positive implications for disease management that will lead to mitigation of escalating honey bee colony losses worldwide. © 2014.
|
|
|
|
|
آدرس
|
usda-ars bee research laboratory,barc-east building,beltsville,md, United States, usda-ars bee research laboratory,barc-east building,beltsville,md, United States, usda-ars bee research laboratory,barc-east building,beltsville,md, United States, microarray core facility,national institute of diabetes and digestive and kidney diseases,national institutes of health,bethesda,md, United States, usda-ars bovine functional genomic laboratory,barc-east building,beltsville,md, United States, department of entomology,university of minnesota,st. paul,mn, United States, department of entomology,university of california,riverside,riverside,ca, United States, usda-ars,carl hayden bee research center,tucson,az, United States, department of biology,university of north carolina,greensboro,greensboro,nc, United States, usda-ars molecular plant pathology laboratory,beltsville,md, United States, department of entomology,university of maryland,college park,md, United States, department of entomology,university of georgia,athens,ga, United States, illinois natural history survey,university of illinois,urbana,il, United States, school of biology and ecology,university of maine,orono,me, United States, usda-ars biometrical consulting services,beltsville,md, United States, center for infection and immunity,mailman school of public health,columbia university,new york,ny, United States, national center for biodefense and infectious disease,george mason university,manassas,va, United States, usda-ars bee research laboratory,barc-east building,beltsville,md, United States, usda-ars bee research laboratory,barc-east building,beltsville,md, United States, college of bee science,fujian agriculture and forestry university,fuzhou,fujian, China, college of animal sciences,zhejiang university,hangzhou,zhejiang, China, institute of apicultural research,chinese academy of agricultural science,beijing, China, eastern bee research institute,yunnan agricultural university,kunming, China, institute for environmental genomics (ieg),university of oklahoma,norman,ok, United States, institute for environmental genomics (ieg),university of oklahoma,norman,ok, United States, institute for environmental genomics (ieg),university of oklahoma,norman,ok, United States, sericulture and apiculture department,national academy of agricultural science,rda suwon, South Korea, agência paulista de tecnologia dos agronegócios/saa-sp,pindamonhangaba,são paulo, Brazil, college of animal sciences,zhejiang university,hangzhou,zhejiang, China, usda-ars bee research laboratory,barc-east building,beltsville,md, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|