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Salmonella enterica Serovar Typhi Conceals the Invasion-Associated Type Three Secretion System from the Innate Immune System by Gene Regulation
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نویسنده
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winter s.e. ,winter m.g. ,poon v. ,keestra a.m. ,sterzenbach t. ,faber f. ,costa l.f. ,cassou f. ,costa e.a. ,alves g.e.s. ,paixão t.a. ,santos r.l. ,bäumler a.j.
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منبع
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plos pathogens - 2014 - دوره : 10 - شماره : 7
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چکیده
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Delivery of microbial products into the mammalian cell cytosol by bacterial secretion systems is a strong stimulus for triggering pro-inflammatory host responses. here we show that salmonella enterica serovar typhi (s. typhi),the causative agent of typhoid fever,tightly regulates expression of the invasion-associated type iii secretion system (t3ss-1) and thus fails to activate these innate immune signaling pathways. the s. typhi regulatory protein tvia rapidly repressed t3ss-1 expression,thereby preventing rac1-dependent,rip2-dependent activation of nf-κb in epithelial cells. heterologous expression of tvia in s. enterica serovar typhimurium (s. typhimurium) suppressed t3ss-1-dependent inflammatory responses generated early after infection in animal models of gastroenteritis. these results suggest that s. typhi reduces intestinal inflammation by limiting the induction of pathogen-induced processes through regulation of virulence gene expression. © 2014 winter et al.
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آدرس
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department of medical microbiology and immunology,school of medicine,university of california,davis,davis,ca,united states,department of microbiology,university of texas southwestern medical center,dallas,tx, United States, department of medical microbiology and immunology,school of medicine,university of california,davis,davis,ca,united states,department of microbiology,university of texas southwestern medical center,dallas,tx, United States, department of medical microbiology and immunology,school of medicine,university of california,davis,davis,ca, United States, department of medical microbiology and immunology,school of medicine,university of california,davis,davis,ca, United States, department of medical microbiology and immunology,school of medicine,university of california,davis,davis,ca, United States, department of medical microbiology and immunology,school of medicine,university of california,davis,davis,ca, United States, departamento de patologia geral,instituto de ciências biológicas,universidade federal de minas gerais,belo horizonte,minas gerais, Brazil, departamento de clinica e cirurgia veterinárias,escola de veterinária,universidade federal de minas gerais,belo horizonte,minas gerais, Brazil, departamento de clinica e cirurgia veterinárias,escola de veterinária,universidade federal de minas gerais,belo horizonte,minas gerais, Brazil, departamento de clinica e cirurgia veterinárias,escola de veterinária,universidade federal de minas gerais,belo horizonte,minas gerais, Brazil, departamento de patologia geral,instituto de ciências biológicas,universidade federal de minas gerais,belo horizonte,minas gerais, Brazil, departamento de clinica e cirurgia veterinárias,escola de veterinária,universidade federal de minas gerais,belo horizonte,minas gerais, Brazil, department of medical microbiology and immunology,school of medicine,university of california,davis,davis,ca, United States
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Authors
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