|
|
|
|
Inflammatory Monocytes Orchestrate Innate Antifungal Immunity in the Lung
|
|
|
|
|
|
|
|
نویسنده
|
espinosa v. ,jhingran a. ,dutta o. ,kasahara s. ,donnelly r. ,du p. ,rosenfeld j. ,leiner i. ,chen c.-c. ,ron y. ,hohl t.m. ,rivera a.
|
|
منبع
|
plos pathogens - 2014 - دوره : 10 - شماره : 2
|
|
چکیده
|
Aspergillus fumigatus is an environmental fungus that causes invasive aspergillosis (ia) in immunocompromised patients. although -cc-chemokine receptor-2 (ccr2) and ly6c-expressing inflammatory monocytes (ccr2+mo) and their derivatives initiate adaptive pulmonary immune responses,their role in coordinating innate immune responses in the lung remain poorly defined. using conditional and antibody-mediated cell ablation strategies,we found that ccr2+mo and monocyte-derived dendritic cells (mo-dcs) are essential for innate defense against inhaled conidia. by harnessing fluorescent aspergillus reporter (flare) conidia that report fungal cell association and viability in vivo,we identify two mechanisms by which ccr2+mo and mo-dcs exert innate antifungal activity. first,ccr2+mo and mo-dcs condition the lung inflammatory milieu to augment neutrophil conidiacidal activity. second,conidial uptake by ccr2+mo temporally coincided with their differentiation into mo-dcs,a process that resulted in direct conidial killing. our findings illustrate both indirect and direct functions for ccr2+mo and their derivatives in innate antifungal immunity in the lung. © 2014 espinosa et al.
|
|
|
|
|
آدرس
|
rutgers,new jersey medical school,department of pediatrics,center for immunity and inflammation,newark,nj,united states,rutgers,graduate school of biomedical sciences,newark,nj, United States, fred hutchinson cancer research center,vaccine and infectious disease division,seattle,wa,united states,department of medicine,infectious disease service,memorial sloan-kettering cancer center,new york,ny, United States, rutgers,new jersey medical school,department of pediatrics,center for immunity and inflammation,newark,nj,united states,rutgers,graduate school of biomedical sciences,newark,nj, United States, fred hutchinson cancer research center,vaccine and infectious disease division,seattle,wa,united states,department of medicine,infectious disease service,memorial sloan-kettering cancer center,new york,ny, United States, rutgers,new jersey medical school,molecular resource facility and high performance and research computing group,office of information technology,rutgers university,newark,nj, United States, rutgers,new jersey medical school,molecular resource facility and high performance and research computing group,office of information technology,rutgers university,newark,nj, United States, rutgers,new jersey medical school,molecular resource facility and high performance and research computing group,office of information technology,rutgers university,newark,nj, United States, memorial sloan kettering cancer center,sloan kettering institute,new york,ny, United States, rutgers,robert wood johnson medical school,department of pharmacology,piscataway,nj, United States, rutgers,robert wood johnson medical school,department of pharmacology,piscataway,nj, United States, fred hutchinson cancer research center,vaccine and infectious disease division,seattle,wa,united states,department of medicine,infectious disease service,memorial sloan-kettering cancer center,new york,ny, United States, rutgers,new jersey medical school,department of pediatrics,center for immunity and inflammation,newark,nj, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|