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Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals
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نویسنده
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klatt n.r. ,bosinger s.e. ,peck m. ,richert-spuhler l.e. ,heigele a. ,gile j.p. ,patel n. ,taaffe j. ,julg b. ,camerini d. ,torti c. ,martin j.n. ,deeks s.g. ,sinclair e. ,hecht f.m. ,lederman m.m. ,paiardini m. ,kirchhoff f. ,brenchley j.m. ,hunt p.w. ,silvestri g.
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منبع
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plos pathogens - 2014 - دوره : 10 - شماره : 8
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چکیده
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A rare subset of hiv-infected individuals,designated viremic non-progressors (vnp),remain asymptomatic and maintain normal levels of cd4+ t-cells despite persistently high viremia. to identify mechanisms potentially responsible for the vnp phenotype,we compared vnps (average >9 years of hiv infection) to hiv-infected individuals who have similar cd4+ t-cell counts and viral load,but who are likely to progress if left untreated (“putative progressors”,pp),thus avoiding the confounding effect of differences related to substantial cd4+ t cell depletion. we found that vnps,compared to pps,had preserved levels of cd4+ stem cell memory cells (tscm (p<0.0001),which was associated with decreased hiv infection of these cells in vnps (r = −0.649,p = 0.019). in addition,vnps had decreased hiv infection in cd4+ central memory (tcm) cells (p = 0.035),and the total number of tcm cells was associated with increased proliferation of memory cd4+ t cells (r = 0.733,p = 0.01). our results suggest that,in hiv-infected vnps,decreased infection of cd4+ tcm and tscm,cells are involved in preservation of cd4+ t cell homeostasis and lack of disease progression despite high viremia. © 2014,public library of science. all rights reserved.
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آدرس
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department of pharmaceutics,washington national primate research center,university of washington,seattle,wa,united states,laboratory of molecular microbiology,national institute of allergy and infectious disease,national institutes of health,bethesda,md, United States, yerkes primate research center,emory vaccine center and department of pathology,emory university,atlanta,ga, United States, department of medicine,university of california san francisco,san francisco,ca, United States, department of pharmaceutics,washington national primate research center,university of washington,seattle,wa, United States, institute of molecular virology,ulm university medical center,ulm, Germany, department of pharmaceutics,washington national primate research center,university of washington,seattle,wa, United States, yerkes primate research center,emory vaccine center and department of pathology,emory university,atlanta,ga, United States, yerkes primate research center,emory vaccine center and department of pathology,emory university,atlanta,ga, United States, ragon institute of mgh,mit and harvard,boston,ma, United States, institute for immunology,university of california irvine,irvine,ca, United States, institute of infectious and tropical diseases,university of brescia,brescia, Italy, department of medicine,university of california san francisco,san francisco,ca, United States, department of medicine,university of california san francisco,san francisco,ca, United States, department of medicine,university of california san francisco,san francisco,ca, United States, department of medicine,university of california san francisco,san francisco,ca, United States, division of infectious diseases,case western reserve university/university hospitals case medical center,cleveland,oh, United States, yerkes primate research center,emory vaccine center and department of pathology,emory university,atlanta,ga, United States, institute of molecular virology,ulm university medical center,ulm, Germany, laboratory of molecular microbiology,national institute of allergy and infectious disease,national institutes of health,bethesda,md, United States, department of medicine,university of california san francisco,san francisco,ca, United States, yerkes primate research center,emory vaccine center and department of pathology,emory university,atlanta,ga, United States
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Authors
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