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Adoptive Transfer of EBV Specific CD8+ T Cell Clones Can Transiently Control EBV Infection in Humanized Mice
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نویسنده
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antsiferova o. ,müller a. ,rämer p.c. ,chijioke o. ,chatterjee b. ,raykova a. ,planas r. ,sospedra m. ,shumilov a. ,tsai m.-h. ,delecluse h.-j. ,münz c.
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منبع
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plos pathogens - 2014 - دوره : 10 - شماره : 8
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چکیده
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Epstein barr virus (ebv) infection expands cd8+ t cells specific for lytic antigens to high frequencies during symptomatic primary infection,and maintains these at significant numbers during persistence. despite this,the protective function of these lytic ebv antigen-specific cytotoxic cd8+ t cells remains unclear. here we demonstrate that lytic ebv replication does not significantly contribute to virus-induced b cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (hunsg mice). however,we report a trend to reduction of ebv-induced lymphoproliferation outside of lymphoid organs upon diminished lytic replication. moreover,we could demonstrate that cd8+ t cells against the lytic ebv antigen bmlf1 can eliminate lytically replicating ebv-transformed b cells from lymphoblastoid cell lines (lcls) and in vivo,thereby transiently controlling high viremia after adoptive transfer into ebv infected hunsg mice. these findings suggest a protective function for lytic ebv antigen-specific cd8+ t cells against ebv infection and against virus-associated tumors in extra-lymphoid organs. these specificities should be explored for ebv-specific vaccine development. © 2014 antsiferova et al.
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آدرس
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viral immunobiology,institute of experimental immunology,university of zürich,zürich, Switzerland, viral immunobiology,institute of experimental immunology,university of zürich,zürich, Switzerland, viral immunobiology,institute of experimental immunology,university of zürich,zürich, Switzerland, viral immunobiology,institute of experimental immunology,university of zürich,zürich, Switzerland, viral immunobiology,institute of experimental immunology,university of zürich,zürich, Switzerland, viral immunobiology,institute of experimental immunology,university of zürich,zürich, Switzerland, neuroimmunology and multiple sclerosis research,department of neurology,university hospital zürich,zürich, Switzerland, neuroimmunology and multiple sclerosis research,department of neurology,university hospital zürich,zürich, Switzerland, division of pathogenesis of virus associated tumors,german cancer research centre (dkfz),heidelberg, Germany, division of pathogenesis of virus associated tumors,german cancer research centre (dkfz),heidelberg, Germany, division of pathogenesis of virus associated tumors,german cancer research centre (dkfz),heidelberg, Germany, viral immunobiology,institute of experimental immunology,university of zürich,zürich, Switzerland
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Authors
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