|
|
|
|
CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells
|
|
|
|
|
|
|
|
نویسنده
|
klatt n.r. ,shudo e. ,ortiz a.m. ,engram j.c. ,paiardini m. ,lawson b. ,miller m.d. ,else j. ,pandrea i. ,estes j.d. ,apetrei c. ,schmitz j.e. ,ribeiro r.m. ,perelson a.s. ,silvestri g.
|
|
منبع
|
plos pathogens - 2010 - دوره : 6 - شماره : 1
|
|
چکیده
|
While cd8+ t cells are clearly important in controlling virus replication during hiv and siv infections,the mechanisms underlying this antiviral effect remain poorly understood. in this study,we assessed the in vivo effect of cd8+ lymphocyte depletion on the lifespan of productively infected cells during chronic sivmac239 infection of rhesus macaques. we treated two groups of animals that were either cd8+ lymphocyte-depleted or controls with antiretroviral therapy,and used mathematical modeling to assess the lifespan of infected cells either in the presence or absence of cd8+ lymphocytes. we found that,in both early (day 57 post-siv) and late (day 177 post-siv) chronic siv infection,depletion of cd8+ lymphocytes did not result in a measurable increase in the lifespan of either short- or long-lived productively infected cells in vivo. this result indicates that the presence of cd8+ lymphocytes does not result in a noticeably shorter lifespan of productively sivinfected cells,and thus that direct cell killing is unlikely to be the main mechanism underlying the antiviral effect of cd8+ t cells in siv-infected macaques with high virus replication.
|
|
|
|
|
آدرس
|
department of pathology and laboratory medicine,university of pennsylvania,philadelphia,pa,united states,yerkes national primate research center,emory university,atlanta,ga, United States, theoretical biology and biophysics,los alamos national laboratory,los alamos,nm, United States, department of pathology and laboratory medicine,university of pennsylvania,philadelphia,pa, United States, department of pathology and laboratory medicine,university of pennsylvania,philadelphia,pa, United States, department of pathology and laboratory medicine,university of pennsylvania,philadelphia,pa, United States, yerkes national primate research center,emory university,atlanta,ga, United States, gilead sciences,inc.,foster city,ca, United States, yerkes national primate research center,emory university,atlanta,ga, United States, tulane national primate research center,tulane health sciences center,tulane university,new orleans,la, United States, aids and cancer virus program,science applications international corporation-frederick,inc.,national cancer institute,frederick,md, United States, tulane national primate research center,tulane health sciences center,tulane university,new orleans,la, United States, beth israel deaconess medical center,harvard medical school,boston,ma, United States, theoretical biology and biophysics,los alamos national laboratory,los alamos,nm, United States, theoretical biology and biophysics,los alamos national laboratory,los alamos,nm, United States, department of pathology and laboratory medicine,university of pennsylvania,philadelphia,pa,united states,yerkes national primate research center,emory university,atlanta,ga, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|